| The dark side of activation-induced cytidine deaminase: relationship with leukemia and beyond. | |
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MedLine Citation:
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PMID: 16720548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Activation-induced cytidine deaminase (AID) is a unique cellular enzyme that can trigger point mutations and chromosomal translocations, both of which potentially disturb normal cellular metabolism and affect cancer initiation and progression. The involvement of AID in the progression of leukemia has been suggested by multiple groups on the basis of observations of the statistical correlation between AID expression and a poor prognosis of B-cell chronic lymphocytic leukemia. The fact that ectopic expression of AID in mice results in tumors of the lung and T-lymphocytes suggests an oncogenic role for AID. The inducible nature of AID expression indicates that AID might be induced and cause oncogenic mutations, even in epithelial tissues, where AID expression is absent or very weak under normal conditions. If AID can be induced in epithelial cells by inflammatory signals, as from B-lymphocytes, it may be involved in various pathologic conditions, including inflammation-and infection-associated cancers, for which the molecular mechanism is largely unknown, despite the clinical significance of these diseases. |
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Authors:
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Kazuo Kinoshita; Taichiro Nonaka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: International journal of hematology Volume: 83 ISSN: 0925-5710 ISO Abbreviation: Int. J. Hematol. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-05-24 Completed Date: 2006-07-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 201-7 Citation Subset: IM |
Affiliation:
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Evolutionary Medicine, Shiga Medical Center Research Institute, Moriyama. kkinoshi.shigamed@mac.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytidine Deaminase Cytosine Deaminase / biosynthesis, genetics* Enzyme Activation / genetics Gene Expression Regulation, Enzymologic* Gene Expression Regulation, Leukemic* Humans Leukemia, Lymphocytic, Chronic, B-Cell / enzymology*, genetics Mice Point Mutation* Prognosis Translocation, Genetic* |
| Chemical | |
Reg. No./Substance:
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EC 3.5.4.-/AICDA (activation-induced cytidine deaminase); EC 3.5.4.1/Cytosine Deaminase; EC 3.5.4.5/Cytidine Deaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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