Document Detail

The danger of "yellow dyes" (tartrazine) to allergic subjects.
MedLine Citation:
PMID:  627044     Owner:  NLM     Status:  MEDLINE    
Oral administration of 50 mg tartrazine to 122 patients with a variety of allergic disorders caused the following reactions: general weakness, heatwaves, palpitations, blurred vision, rhinorrhoea, feeling of suffocation, pruritus and urticaria. There was activation of the fibrinolytic pathway as shown by reduction of plasminogen with high pre-kallikrein and low kallikrein values. Reduction in complement activity (CH50) was seen in three out of sixteen reactions.
I Neuman; R Elian; H Nahum; P Shaked; D Creter
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical allergy     Volume:  8     ISSN:  0009-9090     ISO Abbreviation:  Clin. Allergy     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1978-04-26     Completed Date:  1978-04-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0311172     Medline TA:  Clin Allergy     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  65-8     Citation Subset:  IM    
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MeSH Terms
Azo Compounds / adverse effects*
Complement System Proteins
Drug Hypersensitivity / etiology*
Food Additives / adverse effects*
Hypersensitivity / diagnosis
Immunoglobulin G
Immunoglobulin M
Tartrazine / adverse effects*
Reg. No./Substance:
0/Azo Compounds; 0/Food Additives; 0/Immunoglobulin G; 0/Immunoglobulin M; 1934-21-0/Tartrazine; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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