| dSir2 and longevity in Drosophila. | |
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MedLine Citation:
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PMID: 20728527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The silent information regulator 2 (Sir2 or Sirtuin) family of proteins is highly conserved and has been implicated in the extension of longevity for several species. Mammalian Sirtuins have been shown to affect various aspects of physiology including metabolism, the stress response, cell survival, replicative senescence, inflammation, the circadian rhythm, neurodegeneration, and even cancer. Evidence in Drosophila implicates Sir2 in at least some of the beneficial effects of caloric restriction (CR). CR delays age-related pathology and extends life span in a wide variety of species. Here we will review the evidence linking Drosophila Sir2 (dSir2) to longevity regulation and the pathway associated with CR in Drosophila, as well as the effects of the Sir2 activator resveratrol and potential interactions between dSir2 and p53. |
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Authors:
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Stewart Frankel; Tahereh Ziafazeli; Blanka Rogina |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-08-20 |
Journal Detail:
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Title: Experimental gerontology Volume: 46 ISSN: 1873-6815 ISO Abbreviation: Exp. Gerontol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-19 Completed Date: 2011-08-17 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
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Languages: eng Pagination: 391-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Biology, University of Hartford, West Hartford, CT, 06117, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Caloric Restriction Drosophila Proteins / physiology* Drosophila melanogaster / physiology* Histone Deacetylases / physiology* Longevity / physiology* Models, Animal* Sirtuins / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG023088-07/AG/NIA NIH HHS; R01 AG023088-08/AG/NIA NIH HHS; R01AG 023088/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; EC 3.5.1.-/Sir2 protein, Drosophila; EC 3.5.1.-/Sirtuins; EC 3.5.1.98/Histone Deacetylases |
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