Document Detail

d,1-alpha-Tocopheryl acetate (vitamin E): a long term toxicity and carcinogenicity study in rats.
MedLine Citation:
PMID:  6629668     Owner:  NLM     Status:  MEDLINE    
Rats were fed vitamin E at various dietary concentrations providing dosages of up to 2000 mg/kg bodyweight/day for 104 weeks. Vitamin K supplementation suppressed the induced hypoprothrombinaemia. Growth rate and survival were unaltered by treatment, and, apart from a trend towards fewer mammary tumours in females, the tumour profile was unaffected. Changes in serum liver enzyme activity and in the appearance of the hepatic macrophages suggested a limited hepatic response to vitamin E overload.
G H Wheldon; A Bhatt; P Keller; H Hummler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  53     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  1983  
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  287-96     Citation Subset:  IM    
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MeSH Terms
Blood Cell Count
Growth / drug effects
Liver / enzymology
Organ Size
Prothrombin Time
Sex Factors
Vitamin E / analogs & derivatives*,  toxicity
Vitamin K / pharmacology
alpha-Tocopherol* / analogs & derivatives*
Reg. No./Substance:
0/Carcinogens; 12001-79-5/Vitamin K; 1406-18-4/Vitamin E; 1406-66-2/Tocopherols; 59-02-9/alpha-Tocopherol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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