| d,1-alpha-Tocopheryl acetate (vitamin E): a long term toxicity and carcinogenicity study in rats. | |
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MedLine Citation:
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PMID: 6629668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats were fed vitamin E at various dietary concentrations providing dosages of up to 2000 mg/kg bodyweight/day for 104 weeks. Vitamin K supplementation suppressed the induced hypoprothrombinaemia. Growth rate and survival were unaltered by treatment, and, apart from a trend towards fewer mammary tumours in females, the tumour profile was unaffected. Changes in serum liver enzyme activity and in the appearance of the hepatic macrophages suggested a limited hepatic response to vitamin E overload. |
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Authors:
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G H Wheldon; A Bhatt; P Keller; H Hummler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition Volume: 53 ISSN: 0300-9831 ISO Abbreviation: Int J Vitam Nutr Res Publication Date: 1983 |
Date Detail:
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Created Date: 1983-12-20 Completed Date: 1983-12-20 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 1273304 Medline TA: Int J Vitam Nutr Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 287-96 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Cell Count Carcinogens* Diet Female Growth / drug effects Liver / enzymology Male Organ Size Prothrombin Time Rats Sex Factors Tocopherols Vitamin E / analogs & derivatives*, toxicity Vitamin K / pharmacology alpha-Tocopherol* / analogs & derivatives* |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 12001-79-5/Vitamin K; 1406-18-4/Vitamin E; 1406-66-2/Tocopherols; 59-02-9/alpha-Tocopherol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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