| d-pinitol inhibits RANKL-induced osteoclastogenesis. | |
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MedLine Citation:
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PMID: 22269833 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Numerous studies have indicated that inflammatory cytokines play a major role in osteoclastogenesis, leading to the bone resorption that is frequently associated with osteoporosis. d-pinitol, a 3-methoxy analogue of d-chiroinositol, was identified as an active principle in soy foods and legumes. Here we found that d-pinitol markedly inhibited the receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastic differentiation from bone marrow stromal cells and RAW264.7 macrophage cells. In addition, d-pinitol also reduced RANKL-induced p38 and JNK phosphorylation. Furthermore, RANKL-mediated increase of IKK, IκBα, and p65 phosphorylation and NF-κB-luciferase activity was inhibited by d-pinitol. However, d-pinitol did not affect the proliferation and differentiation of osteoblasts. In addition, d-pinitol also prevented the bone loss induced by ovariectomy in vivo. Our data suggest that d-pinitol inhibits osteoclastogenesis from bone marrow stromal cells and macrophage cells via attenuated RANKL-induced p38, JNK, and NF-κB activation, which in turn protect bone loss from ovariectomy. |
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Authors:
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Shan-Chi Liu; Show-Mei Chuang; Chih-Hsin Tang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-20 |
Journal Detail:
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Title: International immunopharmacology Volume: - ISSN: 1878-1705 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100965259 Medline TA: Int Immunopharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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