| d-Amino acids in aged proteins: Analysis and biological relevance. | |
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MedLine Citation:
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PMID: 21723211 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Homochirality is essential for life. l-Amino acids are exclusively used as substrates for the polymerization and formation of peptides and proteins in living systems. However, d-amino acids, which are enantiomers of l-amino acids, were recently detected in various living organisms in the form of free d-amino acids and d-amino acid residues in peptides and proteins. In particular, d-aspartyl (Asp) residues have been detected in various proteins from diverse tissues of elderly individuals. Here, we describe three important aspects of our research: (i) a method for detecting d-β-Asp at specific sites in particular proteins, (ii) a likely spontaneous mechanism by which Asp residues in proteins invert and isomerize to the d-β-form with age under physiological conditions, (iii) a discussion of factors that favor such a reaction. |
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Authors:
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Noriko Fujii; Yuichi Kaji; Norihiko Fujii |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-12 |
Journal Detail:
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Title: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Volume: - ISSN: 1873-376X ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-7-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101139554 Medline TA: J Chromatogr B Analyt Technol Biomed Life Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Research Reactor Institute, Kyoto University, Kumatori, Sennan, Osaka 590-0494, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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