| The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors. | |
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MedLine Citation:
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PMID: 8973585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The lethal factor of Bacillus anthracis is central to the pathogenesis of anthrax. Its mechanism of action is still unknown. Recently, on the basis of sequence similarities, we suggested that lethal factor might act similarly to leukotriene A4 hydrolase (LTA4), a bifunctional enzyme also endowed with a metallopeptidase activity. Here we show that some inhibitors of the LTA4 hydrolase and metallopeptidase activities of LTA4 hydrolase also affect the cytotoxicity of the anthrax lethal factor on macrophage cell lines, without interfering with the ability of the lethal factor to enter cells. These results support the proposal that anthrax lethal factor might display in the cytosol of intoxicated cells a peptidase activity similar to that of LTA4 hydrolase. |
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Authors:
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A Menard; E Papini; M Mock; C Montecucco |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Biochemical journal Volume: 320 ( Pt 2) ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-01-27 Completed Date: 1997-01-27 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 687-91 Citation Subset: IM |
Affiliation:
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Centro CNR Biomembrane, Università di Padova, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Bacterial* Bacillus anthracis Bacterial Toxins / antagonists & inhibitors, metabolism, toxicity* Cell Survival / drug effects* Enzyme Inhibitors / pharmacology* Epoxide Hydrolases / antagonists & inhibitors* Kinetics Lipoxygenase Inhibitors / pharmacology* Macrophages Metalloendopeptidases / antagonists & inhibitors* Mice Protease Inhibitors / pharmacology* Protein Binding Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Bacterial; 0/Bacterial Toxins; 0/Enzyme Inhibitors; 0/Lipoxygenase Inhibitors; 0/Protease Inhibitors; 0/anthrax toxin; EC 3.3.2.-/Epoxide Hydrolases; EC 3.3.2.-/leukotriene A4 hydrolase; EC 3.4.24.-/Metalloendopeptidases |
| Comments/Corrections | |
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