| The cytostatic effects and mechanism of action of antiviral acyclic adenine nucleotide analogs in L1210 mouse leukemia cells. | |
| | |
MedLine Citation:
|
PMID: 2342627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The growth and DNA synthesis of mouse leukemic cells L1210 in vitro was inhibited by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) by 50% at concentrations of 57.0 and 185.0 mumols/l, respectively, 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) inhibited the cell growth and DNA synthesis at concentrations of 15.5 and 250.0 mumols/l. The 2-amino congeners of the above analogs were still more efficient: The corresponding values for 2-amino-PMEA were 6.0 and 10.0 mumols/l, and for 2-amino-HPMPA 19.5 and 50.0 mumols/l, respectively. The results suggest that probably at least a part of the growth inhibitory action of PMEA is due to mechanisms not related to its interference with the DNA synthesis. |
| | |
Authors:
|
J Veselý; A Merta; I Votruba; I Rosenberg; A Holý |
Related Documents
:
|
3126037 - Regulation of deoxyribonucleic acid polymerase activity in uterine luminal epithelium a... 232527 - Effects of the tumor promoter tpa on the induction of dna synthesis in normal and rsv-t... 21257587 - Prevalence of coxiella burnetii infection in dutch dairy herds based on testing bulk ta... 6496217 - Differential effects of sodium selenite and methylmercury(ii) on membrane permeability ... 12594857 - Reproducibility of oligonucleotide arrays using small samples. 11133987 - Interacting fidelity defects in the replicative dna polymerase of bacteriophage rb69. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neoplasma Volume: 37 ISSN: 0028-2685 ISO Abbreviation: Neoplasma Publication Date: 1990 |
Date Detail:
|
Created Date: 1990-06-25 Completed Date: 1990-06-25 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0377266 Medline TA: Neoplasma Country: CZECHOSLOVAKIA |
Other Details:
|
Languages: eng Pagination: 105-10 Citation Subset: IM |
Affiliation:
|
Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenine
/
analogs & derivatives*,
pharmacology Animals Antiviral Agents / pharmacology* Cell Division / drug effects DNA / biosynthesis Leukemia L1210 / pathology Male Mice Mice, Inbred DBA Organophosphorus Compounds / pharmacology* Phosphonic Acids* Tumor Cells, Cultured / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents; 0/Organophosphorus Compounds; 0/Phosphonic Acids; 106941-25-7/adefovir; 73-24-5/Adenine; 9007-49-2/DNA; 92999-29-6/9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A new approach to the senior practicum.
Next Document: Electrophoretic analysis of DNA modifications induced by cis- and trans-diamminedichloroplatinum (II...