Document Detail

The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells.
MedLine Citation:
PMID:  18793159     Owner:  NLM     Status:  MEDLINE    
Chronic exposure of pancreatic beta-cells to long-chain fatty acids can cause loss of secretory function and enhanced apoptosis by a process of 'lipotoxicity', which may be a contributory factor to the rising incidence of Type 2 diabetes in humans. However, when incubated in vitro, beta-cells respond differentially to long-chain saturated and mono-unsaturated fatty acids, suggesting that these molecules may regulate cell functionality by different mechanisms. In particular, it is clear that, whereas saturated fatty acids [e.g. palmitate (C16:0)] exert detrimental effects on beta-cells, the equivalent mono-unsaturated species [e.g. palmitoleate (C16:1)] are well tolerated. Indeed, mono-unsaturated species are potently cytoprotective. The present review explores the differential effects of these various fatty acids on beta-cell viability and considers the possible mechanisms involved in cytoprotection by mono-unsaturates.
Noel G Morgan; Shalinee Dhayal; Eleftheria Diakogiannaki; Hannah J Welters
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biochemical Society transactions     Volume:  36     ISSN:  0300-5127     ISO Abbreviation:  Biochem. Soc. Trans.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-16     Completed Date:  2008-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506897     Medline TA:  Biochem Soc Trans     Country:  England    
Other Details:
Languages:  eng     Pagination:  905-8     Citation Subset:  IM    
Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth PL6 8BU, UK.
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MeSH Terms
Cell Survival
Fatty Acids, Unsaturated / chemistry,  metabolism*
Insulin-Secreting Cells / metabolism*
Reg. No./Substance:
0/Fatty Acids, Unsaturated

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