| A cytoplasmic clock with the same period as the division cycle in Xenopus eggs. | |
| | |
MedLine Citation:
|
PMID: 6928638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In most species the cell cycle is arrested in the unfertilized egg. After fertilization the cell cycle is reestablished and a rapid series of cleavages ensues. Preceding the first cleavage in Xenopus the egg undergoes a contraction of its cortex, called the "surface contraction wave," which can be visualized by time-lapse cinematography. This wave of contraction is propagated in a circular manner from the animal pole to the equator. We have found that eggs prevented from cleaving by treatment with antimitotic drugs undergo a sequence of periodic surface contraction waves timed with the cleavage cycle in untreated eggs. In addition, artificially activated eggs, which fail to cleave presumably for lack of a functioning centriole, undergo the same periodic contractions. No nuclear material is required for the periodic waves because a separated egg fragment, produced by constricting a fertilized egg, still undergoes contraction waves with the same period as the cleaving nucleated fragment. These results demonstrate that some expression of the cell cycle persists in the absence of any nuclear material or centrioles, suggesting to us that a biological clock exists in the cytoplasm or cortex of vertebrate eggs, which may be involved in timing the cell cycle. |
| | |
Authors:
|
K Hara; P Tydeman; M Kirschner |
Related Documents
:
|
9801068 - Treatment of the budding yeast saccharomyces cerevisiae with the lipid peroxidation pro... 15912358 - Different cell cycle responses of wound healing protagonists to transient in vitro hypo... 11409178 - Fission yeast tor1 functions in response to various stresses including nitrogen starvat... 12921238 - Growth during the cell cycle. 7735218 - A convenient screening test for hypoxic cell radiosensitizers/cytotoxins. 20393778 - The membrane properties of cochlear root cells are consistent with roles in potassium r... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 77 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1980 Jan |
Date Detail:
|
Created Date: 1980-05-23 Completed Date: 1980-05-23 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 462-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biological Clocks* Cell Cycle* Cell Division Cell Nucleus / physiology Colchicine / pharmacology Cytoplasm / physiology* Female Ovum / physiology*, ultrastructure Periodicity Vinblastine / pharmacology Xenopus Zygote / cytology* |
| Chemical | |
Reg. No./Substance:
|
64-86-8/Colchicine; 865-21-4/Vinblastine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fusion of liposomes with mitochondrial inner membranes.
Next Document: DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitro...