Document Detail

The cytology of Langerhans cell histiocytosis (histiocytosis X).
MedLine Citation:
PMID:  1932578     Owner:  NLM     Status:  MEDLINE    
The cytomorphology of 13 cases of Langerhans cell histiocytosis is described. The most striking features were the presence of intranuclear clefts, pale nuclei and inconspicuous nucleoli, together with ample pale cytoplasm, only slight cellular pleomorphism, and an admixture of varying numbers of eosinophils, macrophages and degenerated cells. In 13 of 16 cases investigated ultrastructurally, characteristic Birbeck granules were detected. Out of six cases tested, four exhibited positivity for S-100, and of three cases tested, all were positive for CD1a (leu 6) and HLA-DR. In one case malignant transformation occurred, terminating in monocytic leukaemia.
P Van Heerde; R Maarten Egeler
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cytopathology : official journal of the British Society for Clinical Cytology     Volume:  2     ISSN:  0956-5507     ISO Abbreviation:  Cytopathology     Publication Date:  1991  
Date Detail:
Created Date:  1991-12-03     Completed Date:  1991-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9010345     Medline TA:  Cytopathology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  149-58     Citation Subset:  IM    
Department of Pathology, The Netherlands Cancer Institute, Amsterdam.
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MeSH Terms
Cell Transformation, Neoplastic
Histiocytosis, Langerhans-Cell / pathology*
Infant, Newborn
Islets of Langerhans / pathology*,  ultrastructure
Microscopy, Electron
Middle Aged

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