| Th1/Th2 cytokines balance--yin and yang of reproductive immunology. | |
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MedLine Citation:
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PMID: 15893871 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For years conception of Th2 overbalance during pregnancy has been a paradigm for immunology of reproduction, while Th1 activity has been presented as unwanted component. Studies concerning Th1/Th2 balance in physiological and complicated pregnancy have been reviewed. Th1 activity during early peri-implantation period, premature and term labour not only accompanies but even predominates over Th2 activity. Th1 activity plays important role in promotion of Th2 response, regulation of placentation process, defense against infections and initiation of delivery. Together with Th2 activity it is necessary component of immunological reactions during pregnancy, both activities being inseparable like yin and yang. So paradigm of "Th1-Th2 cooperation" is much closer to reality than "Th2 phenomenon". |
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Authors:
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Jacek R Wilczyński |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 122 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-12 Completed Date: 2006-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 136-43 Citation Subset: IM |
Affiliation:
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Department of Gynecological Surgery, Polish Mother's Health Center Research Institute, 93-338 Lodz, 281/289 Rzgowska St., Poland. jrwil@post.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Pregnancy / immunology* Th1 Cells / immunology* Th2 Cells / immunology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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