Document Detail

The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio.
MedLine Citation:
PMID:  22210003     Owner:  NLM     Status:  MEDLINE    
Macrophage migration inhibitory factor (MIF) plays versatile roles in the immune system. MIF is also widely expressed during embryonic development, particularly in the nervous system, although its roles in neural development are only beginning to be understood. Evidence from frogs, mice and zebrafish suggests that MIF has a major role as a neurotrophin in the early development of sensory systems, including the auditory system. Here we show that the zebrafish mif pathway is required for both sensory hair cell (HC) and sensory neuronal cell survival in the ear, for HC differentiation, semicircular canal formation, statoacoustic ganglion (SAG) development, and lateral line HC differentiation. This is consistent with our findings that MIF is expressed in the developing mammalian and avian auditory systems and promotes mouse and chick SAG neurite outgrowth and neuronal survival, demonstrating key instructional roles for MIF in vertebrate otic development.
Yu-chi Shen; Deborah L Thompson; Meng-Kiat Kuah; Kah-Loon Wong; Karen L Wu; Stephanie A Linn; Ethan M Jewett; Alexander Chong Shu-Chien; Kate F Barald
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-12-22
Journal Detail:
Title:  Developmental biology     Volume:  363     ISSN:  1095-564X     ISO Abbreviation:  Dev. Biol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-16     Completed Date:  2012-05-21     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-94     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.
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MeSH Terms
Cell Differentiation / genetics
Ear, Inner / embryology,  metabolism*
Embryo, Nonmammalian / cytology,  embryology,  metabolism
Ganglia, Sensory / embryology,  metabolism
Gene Expression Profiling
Gene Expression Regulation, Developmental / drug effects
Gene Knockdown Techniques
Hair Cells, Auditory / metabolism
Histone Deacetylase Inhibitors / pharmacology
Hydroxamic Acids / pharmacology
Macrophage Migration-Inhibitory Factors / genetics*,  metabolism
Nerve Growth Factors / genetics*
Pyrimidines / pharmacology
Receptors, Immunologic / genetics
Reverse Transcriptase Polymerase Chain Reaction
Semicircular Canals / embryology,  metabolism
Sensory Receptor Cells / cytology,  metabolism
Time Factors
Zebrafish / embryology,  genetics*
Zebrafish Proteins / genetics*
Grant Support
2 R01 DC04184/DC/NIDCD NIH HHS; 3R01DC004184-08W1/DC/NIDCD NIH HHS; P60-DK20572/DK/NIDDK NIH HHS; R01 DC004184-01A1S1/DC/NIDCD NIH HHS; R01 DC004184-02/DC/NIDCD NIH HHS; R01 DC004184-03/DC/NIDCD NIH HHS; R01 DC004184-03S1/DC/NIDCD NIH HHS; R01 DC004184-04A1/DC/NIDCD NIH HHS; R01 DC004184-05/DC/NIDCD NIH HHS; R01 DC004184-06/DC/NIDCD NIH HHS; R01 DC004184-07/DC/NIDCD NIH HHS; R01 DC004184-08/DC/NIDCD NIH HHS; R01 DC004184-08S1/DC/NIDCD NIH HHS; T32 HG00040/HG/NHGRI NIH HHS
Reg. No./Substance:
0/4-iodo-6-phenylpyrimidine; 0/Histone Deacetylase Inhibitors; 0/Hydroxamic Acids; 0/Macrophage Migration-Inhibitory Factors; 0/Nerve Growth Factors; 0/Pyrimidines; 0/Receptors, Immunologic; 0/Zebrafish Proteins; 0/macrophage migration inhibitory factor receptor; 3X2S926L3Z/trichostatin A

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