Document Detail

The cytokine and chemokine network in psoriasis.
MedLine Citation:
PMID:  18021894     Owner:  NLM     Status:  MEDLINE    
Creation and maintenance of psoriatic plaques require a multicellular conspiracy by which prepsoriatic skin becomes infiltrated by a variety of immunocytes triggering changes in the behavior of epidermal keratinocytes and endothelial cells. These complex cellular events require coordination in space and time to achieve the mature plaque. Key molecular coordinators dictating behavior and movement of cells within plaques include cytokines as well as chemokines. These mediators of inflammation play fundamentally important roles in the pathophysiology of psoriasis. The purpose of this chapter is to provide an updated review of cytokine and chemokine networks in psoriatic skin lesions.
Brian J Nickoloff; Hong Xin; Frank O Nestle; Jian-Zhong Qin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Clinics in dermatology     Volume:  25     ISSN:  0738-081X     ISO Abbreviation:  Clin. Dermatol.     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406412     Medline TA:  Clin Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  568-73     Citation Subset:  IM    
Department of Pathology and Skin Disease Research Program, Oncology Institute and Cardinal Bernardin Cancer Center, Loyola University Chicago Medical Center, Maywood, IL 60153, USA.
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MeSH Terms
Chemokines / immunology,  metabolism*
Cytokines / immunology,  metabolism*
Epidermis / immunology,  metabolism
Inflammation / immunology,  metabolism
Keratinocytes / immunology,  metabolism
Psoriasis / immunology*,  metabolism*
Grant Support
Reg. No./Substance:
0/Chemokines; 0/Cytokines

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