Document Detail

A cysteine proteinase, which cleaves human C3, the third component of complement, is involved in tumorigenicity and metastasis of human melanoma.
MedLine Citation:
PMID:  8542576     Owner:  NLM     Status:  MEDLINE    
The DM-4 human melanoma cell line, which is highly metastatic in nude mice, expresses a C3-cleaving activity that proteolyzes labeled as well as unlabeled human C3. This C3-cleaving activity is a cysteine proteinase characterized by a M(r) 41,000. The p41 proteinase shares antigenic determinants with murine p39 procathepsin-L and human procathepsin-L. Preincubation of DM-4 cells with anti-p39 F(ab')2 induced up to 45% decrease in their complement resistance. Pretreatment of DM-4 cells with anti-p39 Ab strongly inhibited their tumorigenicity and significantly decreased their metastatic potential in nude mice. Thus, the p41 C3-cleaving proteinase contributes to tumorigenicity and metastasis of human melanoma DM-4 cells.
D Jean; M Bar-Eli; S Huang; K Xie; F Rodrigues-Lima; J Hermann; R Frade
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  56     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-02-13     Completed Date:  1996-02-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  254-8     Citation Subset:  IM    
Immunochimie des Régulations Cellulaires et des Interactions Virales, INSERM U.354, Centre INSERM, Hôpital Saint-Antoine, Paris, France.
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MeSH Terms
Cathepsin L
Cathepsins / immunology,  metabolism
Complement C3 / metabolism*
Cysteine Endopeptidases / immunology,  metabolism*
Epitopes / metabolism
Lung Neoplasms / enzymology,  secondary
Melanoma / enzymology*,  pathology*,  secondary
Mice, Nude
Neoplasm Metastasis
Neoplasm Proteins / immunology,  metabolism*
Neoplasm Transplantation
Tumor Cells, Cultured
Grant Support
Reg. No./Substance:
0/Complement C3; 0/Epitopes; 0/Neoplasm Proteins; EC 3.4.-/Cathepsins; EC 3.4.-/Endopeptidases; EC 3.4.22.-/Cysteine Endopeptidases; EC protein, human; EC L; EC protein, mouse

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