| A cyclooxygase-2 inhibitor NS-398-enhanced apoptosis of esophageal carcinoma cell EC9706 by adjusting expression of survivin and caspase-3. | |
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MedLine Citation:
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PMID: 21329005 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The aim of this study is to examine the effect and mechanism of a selective cyclooxygenase-2 (COX-2) inhibitor NS-398 on inducing apoptosis of esophageal cancer cells. After the treatment with NS-398 on esophageal carcinoma EC9706 cell, MTT assay was used to observe the inhibition of EC9706 cell growth and apoptosis was determined by electronic microscopy and flow cytometry. The expression of survivin and caspase-3 was examined using immunocytochemical technique. The dose of 0.01–0.1 mM NS398 showed the inhibitory effect on growth of EC9706 cell lines and induce apoptosis in a dose- and time-effective manner; moreover, NS-398 also downregulated the level of expression of survivin and elevated the expression of capase-3. NS-398 can induce apoptosis of the esophageal carcinoma EC9706 cells by means of adjusting expression of survivin and caspase-3. |
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Authors:
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Shengbao Li; Dean Tian; Pei Fei; Yuanjun Gao; Zihua Chen; Qiang Wang; Qiang Tong |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer investigation Volume: 29 ISSN: 1532-4192 ISO Abbreviation: Cancer Invest. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8307154 Medline TA: Cancer Invest Country: England |
Other Details:
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Languages: eng Pagination: 102-6 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, TONG JI Hospital, TONGJI Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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