Document Detail

The cyclin-dependent kinase inhibitors p19(Ink4d) and p27(Kip1) are coexpressed in select retinal cells and act cooperatively to control cell cycle exit.
MedLine Citation:
PMID:  11906209     Owner:  NLM     Status:  MEDLINE    
Cyclin-dependent kinase inhibitors (cdki's), including p19(Ink4d) and p27(Kip1), mediate exit from the cell cycle. To determine the function of these cdki's in regulating neurogenesis, we examined retina from wild-type, Ink4d-null, and Ink4d/Kip1-double null animals. Ink4d was expressed in progenitors and select neurons in the mature retina. Ink4d-null retina showed an extended period of proliferation, followed by apoptosis. Colabeling for p19(Ink4d) and p27(Kip1) revealed that a subpopulation of cells expressed both inhibitors. Deletion of Ink4d and Kip1 resulted in continued proliferation that was synergistic. This hyperproliferation led to an increase in number of horizontal cells and differentiated neurons reentering the cell cycle. Deletion of Ink4d and Kip1 also exacerbated the retinal dysplasia observed in Kip1-null mice, which was shown to be partly dependent on p53. These data indicate that select retinal cells express both p19(Ink4d) and p27(Kip1) and that they act cooperatively to ensure cell cycle exit.
Justine J Cunningham; Edward M Levine; Frederique Zindy; Olga Goloubeva; Martine F Roussel; Richard J Smeyne
Related Documents :
9398669 - A wd repeat protein controls the cell cycle and differentiation by negatively regulatin...
16822929 - The cannabinoid cb1 receptor antagonist rimonabant (sr141716) inhibits human breast can...
11444049 - Regulation of the embryonic cell proliferation by drosophila cyclin d and cyclin e comp...
21623169 - β-cell replication and islet neogenesis following partial pancreatectomy.
15557399 - Progress of cell proliferation in striated muscle tissues during development of the mou...
20066559 - Cyclin d3/cdk11(p58) complex involved in schwann cells proliferation repression caused ...
23141799 - Hdac inhibitor-based therapies: can we interpret the code?
25079679 - Expression of acid-sensing ion channels in nucleus pulposus cells of the human interver...
1750709 - Occurrence of epidermal growth factor-binding sites during differentiation of cementobl...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular and cellular neurosciences     Volume:  19     ISSN:  1044-7431     ISO Abbreviation:  Mol. Cell. Neurosci.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-21     Completed Date:  2002-08-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9100095     Medline TA:  Mol Cell Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  359-74     Citation Subset:  IM    
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amacrine Cells / cytology*,  physiology
Cell Cycle Proteins / genetics*
Cell Death / physiology
Cell Differentiation / physiology
Cell Division / physiology
Cyclin-Dependent Kinase Inhibitor p16 / genetics*
Cyclin-Dependent Kinase Inhibitor p19
Cyclin-Dependent Kinase Inhibitor p27
Gene Deletion
Gene Expression Regulation, Developmental
Genes, cdc / physiology*
Mice, Inbred C57BL
Mice, Knockout
Retinal Dysplasia / genetics,  pathology
Retinal Ganglion Cells / cytology*,  physiology
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Proteins / genetics*
Grant Support
Reg. No./Substance:
0/Cdkn1b protein, mouse; 0/Cdkn2d protein, mouse; 0/Cell Cycle Proteins; 0/Cyclin-Dependent Kinase Inhibitor p16; 0/Cyclin-Dependent Kinase Inhibitor p19; 0/Tumor Suppressor Protein p53; 0/Tumor Suppressor Proteins; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Laminets: laminin- and netrin-related genes expressed in distinct neuronal subsets.
Next Document:  DN-cadherin is required for spatial arrangement of nerve terminals and ultrastructural organization ...