Document Detail


The cyclic guanosine monophosphate/B-type natriuretic peptide ratio and mortality in advanced heart failure.
MedLine Citation:
PMID:  19168517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Attenuation of the effects of natriuretic peptides has been demonstrated in animal models but studies in humans are scarce, particularly concerning renal attenuation. We investigated the attenuation of B-type natriuretic peptide (BNP) in chronic advanced heart failure (HF).
METHODS AND RESULTS: We included 62 outpatients with HF and severe left ventricular systolic dysfunction. Cases had at least one hospital admission or emergency department visit for acute HF in the previous year and were in NYHA class III/IV despite optimized therapy. The individual age- and sex-matched controls were symptomatically controlled (NYHA I and II). We collected 24 h urine and a blood sample from all patients. Plasma BNP and plasma (pcGMP) and urine cyclic guanosine monophosphate (ucGMP) were measured. Patients were followed for 3 months for hospital admission or all-cause death. ucGMP to plasma BNP (ucGMP/BNP) ratio was attenuated in cases vs. controls [median (IQR): 8354 (4293-16,456) vs. 12,693 (6896-22,851)]. There were no differences in pcGMP to BNP (pcGMP/BNP) ratio or urine cGMP excretion. Patients with worse outcome had lower pcGMP/BNP [260 (86-344) vs. 381 (244-728) in patients without adverse outcome events] and lower ucGMP/BNP [4146 (2207-9363) vs. 10,922 (7495-19,971)].
CONCLUSION: Renal NP's second messenger production is attenuated in advanced HF. Patients with worse outcome have lower ucGMP/BNP and pcGMP/BNP ratios.
Authors:
Patrícia Lourenço; José Paulo Araújo; Ana Azevedo; António Ferreira; Paulo Bettencourt
Related Documents :
19477397 - The role of n-terminal pro-brain natriuretic peptide and echocardiography for screening...
20666267 - Perioperative brain natriuretic peptide in off-pump coronary artery bypass.
9486257 - Downregulation of 5'-nucleotidase in rabbit heart during coronary underperfusion.
11266187 - Prognostic value of iodine-123-metaiodobenzylguanidine imaging and cardiac natriuretic ...
19284067 - Long-term follow-up of percutaneous coronary intervention of unprotected left main lesi...
10150927 - Transcatheter radiofrequency ablation in the canine right atrium.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of heart failure     Volume:  11     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-04-16     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  185-90     Citation Subset:  IM    
Affiliation:
Serviço de Medicina Interna, Hospital S. João, Faculdade de Medicina da Universidade do Porto, Unidade I&D Cardiovascular do Porto, 4202-451 Porto, Portugal. pamlourenco@yahoo.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Chronic Disease
Creatinine / blood
Cyclic GMP / metabolism*
Female
Heart Failure / metabolism,  mortality*,  physiopathology
Humans
Male
Natriuretic Peptide, Brain / blood*
Second Messenger Systems
Ventricular Dysfunction, Left / complications
Chemical
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain; 60-27-5/Creatinine; 7665-99-8/Cyclic GMP
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prevalence and prognostic significance of adrenergic escape during chronic beta-blocker therapy in c...
Next Document:  Diagnosis of heart failure with preserved ejection fraction: improved accuracy with the use of marke...