| The cyanobacterial origin of potent anticancer agents originally isolated from sea hares. | |
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MedLine Citation:
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PMID: 12369878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is increasingly evident that the true biological origin of many metabolites originally isolated from certain marine macroorganisms is cyanobacterial. For example, several dolastatins, potent cytotoxic compounds originally derived from the sea hare Dolabella auricularia, have now been isolated from marine cyanobacteria of the genera Lyngbya and Symploca. This review discusses the isolation of dolastatins and close structural analogues from cyanobacteria. Biosynthetic signatures of metabolites isolated from sea hares, but which are most probably cyanobacterial in origin, are also presented. Finally, some more complex ecology involving movement of cyanobacterial metabolites through the marine food web is presented. |
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Authors:
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H Luesch; G G Harrigan; G Goetz; F D Horgen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current medicinal chemistry Volume: 9 ISSN: 0929-8673 ISO Abbreviation: Curr. Med. Chem. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-08 Completed Date: 2003-03-13 Revised Date: 2007-02-12 |
Medline Journal Info:
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Nlm Unique ID: 9440157 Medline TA: Curr Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1791-806 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, USA. hluesch@gold.chem.hawaii.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / chemistry*, isolation & purification Aplysia / chemistry Cyanobacteria / chemistry* Humans Oligopeptides Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Oligopeptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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