Document Detail

The cyanobacterial origin of potent anticancer agents originally isolated from sea hares.
MedLine Citation:
PMID:  12369878     Owner:  NLM     Status:  MEDLINE    
It is increasingly evident that the true biological origin of many metabolites originally isolated from certain marine macroorganisms is cyanobacterial. For example, several dolastatins, potent cytotoxic compounds originally derived from the sea hare Dolabella auricularia, have now been isolated from marine cyanobacteria of the genera Lyngbya and Symploca. This review discusses the isolation of dolastatins and close structural analogues from cyanobacteria. Biosynthetic signatures of metabolites isolated from sea hares, but which are most probably cyanobacterial in origin, are also presented. Finally, some more complex ecology involving movement of cyanobacterial metabolites through the marine food web is presented.
H Luesch; G G Harrigan; G Goetz; F D Horgen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current medicinal chemistry     Volume:  9     ISSN:  0929-8673     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-08     Completed Date:  2003-03-13     Revised Date:  2007-02-12    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1791-806     Citation Subset:  IM    
Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
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MeSH Terms
Antineoplastic Agents / chemistry*,  isolation & purification
Aplysia / chemistry
Cyanobacteria / chemistry*
Structure-Activity Relationship
Reg. No./Substance:
0/Antineoplastic Agents; 0/Oligopeptides

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