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The cyanobacterial clock and metabolism.
MedLine Citation:
PMID:  24667330     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cyanobacteria possess the simplest known circadian clock, which presents a unique opportunity to study how rhythms are generated and how input signals from the environment reset the clock time. The kaiABC locus forms the core of the oscillator, and the remarkable ability to reconstitute oscillations using purified KaiABC proteins has allowed researchers to study mechanism using the tools of quantitative biochemistry. Autotrophic cyanobacteria experience major shifts in metabolism following a light-dark transition, and recent work suggests that input mechanisms that couple the day-night cycle to the clock involve energy and redox metabolites acting directly on clock proteins. We offer a summary of the current state of knowledge in this system and present a perspective for future lines of investigation.
Authors:
Gopal Pattanayak; Michael J Rust
Publication Detail:
Type:  REVIEW     Date:  2014-3-22
Journal Detail:
Title:  Current opinion in microbiology     Volume:  18C     ISSN:  1879-0364     ISO Abbreviation:  Curr. Opin. Microbiol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815056     Medline TA:  Curr Opin Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  90-95     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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