Document Detail

The cutoff values of intrathecal interleukin 8 and 6 for predicting the neurological outcome in cardiac arrest victims.
MedLine Citation:
PMID:  19010583     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the changes in inflammatory cytokines, such as interleukin (IL)-8 and IL-6, in the cerebrospinal fluid (CSF) and serum, and to identify any correlations with the neurological outcomes in patients resuscitated from cardiopulmonary arrest (CPA). MATERIALS AND METHODS: This study was designed as a prospective clinical trial. Thirteen patients, who were resuscitated from out-of-hospital CPA and survived for more than 48 h, were enrolled in this study. Arterial blood was taken from the patients at 48 h after the return of spontaneous circulation (ROSC) and CSF was taken by lumbar puncture at the same time. RESULTS: In the CSF, the median levels of IL-8 and IL-6 in the patients resuscitated from CPA were significantly higher than those in the control subjects (1311 pg/ml vs 82 pg/ml, P<0.001; 2040 pg/ml vs 1 pg/ml, P<0.001, respectively). The Glasgow Outcome Scale (GOS) score evaluated at 6 months after the ROSC correlated significantly with the levels of IL-8 and IL-6. The cutoff values and sensitivity values with 100% specificity for the prediction of an unfavorable neurological outcome were 1423 pg/ml and 86% for IL-8, and 2708 pg/ml and 86% for IL-6, respectively. CONCLUSION: We demonstrated the cutoff values of IL-8 and IL-6 in the CSF to predict the neurological outcome in the patients resuscitated from CPA. The excessive inflammatory cytokine reactions in the brain might therefore be related to the poor neurological outcome in patients with post-resuscitation encephalopathy.
Yasutaka Oda; Ryosuke Tsuruta; Shunji Kasaoka; Takeshi Inoue; Tsuyoshi Maekawa
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-17
Journal Detail:
Title:  Resuscitation     Volume:  80     ISSN:  0300-9572     ISO Abbreviation:  Resuscitation     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-05-15     Revised Date:  2009-08-25    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  189-93     Citation Subset:  IM    
Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Ube, Yamaguchi 755-8505, Japan.
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MeSH Terms
Cardiopulmonary Resuscitation
Glasgow Outcome Scale*
Heart Arrest / blood*,  cerebrospinal fluid*,  therapy
Hypothermia, Induced
Interleukin-6 / analysis*
Interleukin-8 / analysis*
Middle Aged
Outcome Assessment (Health Care)
Prospective Studies
Recovery of Function
Sensitivity and Specificity
Reg. No./Substance:
0/Interleukin-6; 0/Interleukin-8

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