Document Detail

The cutaneous side-effects of hydroxyurea.
MedLine Citation:
PMID:  11012636     Owner:  NLM     Status:  MEDLINE    
The cutaneous side-effects of long-term hydroxyurea therapy are not widely known and only rarely reported. We report on a patient who developed widespread skin changes, including the recently recognized hydroxyurea dermopathy, during long-term treatment with hydroxyurea for polycythaemia rubra vera. The time course of the clinical changes suggests that they result from direct toxicity of hydroxyurea on the basal layer of the epidermis and mucosal surfaces. We aim to increase clinical awareness of this problem.
H S Young; A S Khan; J R Kendra; I H Coulson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and laboratory haematology     Volume:  22     ISSN:  0141-9854     ISO Abbreviation:  Clin Lab Haematol     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-11-29     Completed Date:  2000-11-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907061     Medline TA:  Clin Lab Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  229-32     Citation Subset:  IM    
Department of Dermatology, Burnley General Hospital, Burnley, UK.
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MeSH Terms
Alopecia / chemically induced
Carcinoma, Squamous Cell / chemically induced
Hydroxyurea / adverse effects*,  therapeutic use
Keratosis / chemically induced
Polycythemia Vera / complications,  drug therapy
Skin Diseases / chemically induced*,  pathology
Skin Neoplasms / chemically induced
Skin Pigmentation / drug effects
Reg. No./Substance:

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