Document Detail

The current treatment of pulmonary hypertension.
MedLine Citation:
PMID:  20073161     Owner:  NLM     Status:  MEDLINE    
Pulmonary vascular hypertension in general is a progressive, nearly always fatal condition that until recently has had very few treatment options. Our understanding of the pulmonary vascular disease process has opened the window to earlier screening techniques, diagnosis, and treatment options. However, all current treatment options are complex and expensive and therefore require clinical support strategies often necessitating specialized pulmonary hypertension treatment centers. Whether idiopathic or secondary, pulmonary arterial hypertension is characterized by the deregulated proliferation of pulmonary artery endothelial cells and intimal smooth muscle cells, both resistant to cellular apoptosis. Early recognition of such disregulation may lead to earlier diagnosis and treatment and thus alteration in the disease process. Screening of high-risk populations such as those with connective tissue disorders, HIV disease, congenital heart disease, portal hypertension, and those exposed to certain drugs and toxins such as methamphetamines and the diet drugs Dexfenfluramine and Fenfluramine is of utmost importance. Similarly, early symptom recognition in these high-risk groups is essential to earlier diagnosis and treatment.
Kenneth Scott Lloyd
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Methodist DeBakey cardiovascular journal     Volume:  5     ISSN:  1947-6094     ISO Abbreviation:  Methodist Debakey Cardiovasc J     Publication Date:  2009  
Date Detail:
Created Date:  2010-01-15     Completed Date:  2010-03-04     Revised Date:  2012-08-17    
Medline Journal Info:
Nlm Unique ID:  101508600     Medline TA:  Methodist Debakey Cardiovasc J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-3     Citation Subset:  IM    
Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Cardiac Surgical Procedures
Clinical Trials as Topic
Diagnostic Imaging
Disease Progression
Drug Therapy, Combination
Hypertension, Pulmonary / diagnosis*,  therapy*
Phosphodiesterase Inhibitors / therapeutic use
Risk Factors
Vasodilator Agents / therapeutic use
Reg. No./Substance:
0/Antihypertensive Agents; 0/Phosphodiesterase Inhibitors; 0/Vasodilator Agents

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