| The current treatment of pulmonary hypertension. | |
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MedLine Citation:
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PMID: 20073161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary vascular hypertension in general is a progressive, nearly always fatal condition that until recently has had very few treatment options. Our understanding of the pulmonary vascular disease process has opened the window to earlier screening techniques, diagnosis, and treatment options. However, all current treatment options are complex and expensive and therefore require clinical support strategies often necessitating specialized pulmonary hypertension treatment centers. Whether idiopathic or secondary, pulmonary arterial hypertension is characterized by the deregulated proliferation of pulmonary artery endothelial cells and intimal smooth muscle cells, both resistant to cellular apoptosis. Early recognition of such disregulation may lead to earlier diagnosis and treatment and thus alteration in the disease process. Screening of high-risk populations such as those with connective tissue disorders, HIV disease, congenital heart disease, portal hypertension, and those exposed to certain drugs and toxins such as methamphetamines and the diet drugs Dexfenfluramine and Fenfluramine is of utmost importance. Similarly, early symptom recognition in these high-risk groups is essential to earlier diagnosis and treatment. |
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Authors:
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Kenneth Scott Lloyd |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Methodist DeBakey cardiovascular journal Volume: 5 ISSN: 1947-6094 ISO Abbreviation: Methodist Debakey Cardiovasc J Publication Date: 2009 |
Date Detail:
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Created Date: 2010-01-15 Completed Date: 2010-03-04 Revised Date: 2012-08-17 |
Medline Journal Info:
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Nlm Unique ID: 101508600 Medline TA: Methodist Debakey Cardiovasc J Country: United States |
Other Details:
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Languages: eng Pagination: 20-3 Citation Subset: IM |
Affiliation:
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Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Antihypertensive Agents / therapeutic use Cardiac Surgical Procedures Clinical Trials as Topic Diagnostic Imaging Disease Progression Drug Therapy, Combination Electrocardiography Humans Hypertension, Pulmonary / diagnosis*, therapy* Phosphodiesterase Inhibitors / therapeutic use Risk Factors Vasodilator Agents / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Phosphodiesterase Inhibitors; 0/Vasodilator Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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