Document Detail

A curious case of haemolysis, seizure and acute renal failure associated with pregnancy.
MedLine Citation:
PMID:  24482089     Owner:  NLM     Status:  Publisher    
Differential diagnosis between thrombotic microangiopathies in pregnancy is challenging due to overlapping clinical and pathological findings and the rapid progression of disease. We present here an unusual case of Haemolysis, Elevated Liver enzymes and Low Platelets (HELLP) syndrome, which represents this diagnostic dilemma. The patient was treated with steroids and plasma exchange, leading to a favourable outcome. Subsequent genetic testing for complement dysregulation revealed a previously unknown variant in intron 3 of the gene coding for the alternative complement pathway factor H: (c.350+9T>C). We discuss here the diagnostic dilemma presented, the treatment pathway in the current literature, and the potential involvement of complement deregulation in severe HELLP. This case underlines the complexity in the diagnosis and management of pregnancy-related thrombotic microangiopathies.
Konstantinos Koutroutsos; Jennifer Jardine; Louise Ross; Aris Papageorghiou; Roberto Stasi; Debasish Banerjee
Related Documents :
7976239 - Equality in health and health care during pregnancy. a prospective population-based stu...
18853639 - Domestic violence, contraceptive use, and unwanted pregnancy in rural india.
1295949 - Prenatal care in primary health care centers of al hassa, saudi arabia.
17184969 - The effectiveness of teratology information services (tis).
19204859 - Problematic integration in pregnancy and childbirth: contrasting approaches to uncertai...
20148289 - A successful implementation of e-epidemiology: the danish pregnancy planning study 'sna...
3469999 - Tubal resection and anastomosis. ii. isthmic salpingitis.
22713499 - Twin-twin transfusion syndrome.
2198919 - Thrombin-antithrombin iii complex levels in normal pregnancy with hypertensive disorder...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-31
Journal Detail:
Title:  Journal of nephrology     Volume:  -     ISSN:  1724-6059     ISO Abbreviation:  J. Nephrol.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9012268     Medline TA:  J Nephrol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Monomethyl-4-chloroindolyl-3-acetyl-L-aspartate and absence of indolyl-3-acetic acid in immature see...
Next Document:  Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomize...