Document Detail

A curious case of anti-D antibody titer.
MedLine Citation:
PMID:  19879523     Owner:  NLM     Status:  MEDLINE    
RhD alloimmunization remains a threat to 1% of the 10% of RhD-negative women in the United States who are giving birth to RhD-positive fetuses despite routine antenatal and postpartum administration of Rh(o)D immune globulin (RhIG). This report examines the clinical course of an RhD-negative woman who developed a high anti-D antibody titer during her pregnancy while carrying an RhD-positive female fetus yet had a negative antibody screen at the time she gave birth. Although she delivered a healthy newborn unaffected by hemolytic disease, subsequent pregnancies will be treated as though she is RhD alloimmunized. The discussion below includes possible causes for the abrupt rise in this woman's anti-D antibody titer, a review of the complex Rh system and cellular anamnestic response, and current fetal surveillance for hemolytic disease of the fetus and newborn.
Jennifer G Hensley; Katherine P Coughlin; Laura L Klein
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Publication Detail:
Type:  Case Reports; Clinical Conference; Journal Article    
Journal Detail:
Title:  Journal of midwifery & women's health     Volume:  54     ISSN:  1542-2011     ISO Abbreviation:  J Midwifery Womens Health     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-11-02     Completed Date:  2010-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909407     Medline TA:  J Midwifery Womens Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  497-502     Citation Subset:  IM; N    
University of Colorado Denver, College of Nursing, Education 2 North, 13120 E. 19th St., Box C-288, Aurora, CO 80045, USA.
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MeSH Terms
Erythroblastosis, Fetal / prevention & control*
Fetal Monitoring
Isoantibodies / blood*
Prenatal Care / standards
Rh Isoimmunization / diagnosis*
Rh-Hr Blood-Group System / adverse effects,  blood
Reg. No./Substance:
0/Isoantibodies; 0/RHO(D) antibody; 0/Rh-Hr Blood-Group System

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