| The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions. | |
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MedLine Citation:
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PMID: 17765895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ErbB-3 receptor binding protein (Ebp1) is a member of the proliferation-associated 2G4 (PA2G4) family implicated in regulation of cell growth and differentiation. Here, we report the crystal structure of the human Ebp1 at 1.6 A resolution. The protein has the conserved pita bread fold of methionine aminopeptidases, but without the characteristic enzymatic activity. Moreover, Ebp1 is known to interact with a number of proteins and RNAs involved in either transcription regulation or translation control. The structure provides insights in how Ebp1 discriminates between its different interaction partners. |
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Authors:
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Eva Kowalinski; Gert Bange; Bettina Bradatsch; Ed Hurt; Klemens Wild; Irmgard Sinning |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-27 |
Journal Detail:
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Title: FEBS letters Volume: 581 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-11 Completed Date: 2008-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 4450-4 Citation Subset: IM |
Affiliation:
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Heidelberg University Biochemistry Center (BZH), INF 328, D-69120 Heidelberg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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chemistry*,
genetics,
metabolism* Aminopeptidases / chemistry* Binding Sites Crystallography, X-Ray Humans Hydrophobicity Models, Molecular Protein Binding Protein Structure, Secondary Protein Structure, Tertiary RNA, Ribosomal, 5S / metabolism RNA-Binding Proteins / chemistry*, genetics, metabolism* Recombinant Proteins / chemistry, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/PA2G4 protein, human; 0/RNA, Ribosomal, 5S; 0/RNA-Binding Proteins; 0/Recombinant Proteins; EC 3.4.11.-/Aminopeptidases; EC 3.4.11.18/methionyl aminopeptidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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