| The 'cryptic' mechanism of action of glucagon-like peptide-2. | |
| | |
MedLine Citation:
|
PMID: 21527727 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Glucagon-like peptide-2 (GLP-2) is a peptide hormone with multiple beneficial effects on the intestine, including expansion of the mucosal surface area through stimulation of crypt cell proliferation, as well as enhancement of nutrient digestion and absorption. Recent advances in clinical trials involving GLP-2 necessitate elucidation of the exact signaling pathways by which GLP-2 acts. In particular, the GLP-2 receptor has been localized to several intestinal cell types that do not include the proliferating crypt cells, and the actions of GLP-2 have thus been linked to a complex network of indirect mediators that induce diverse signaling pathways. The intestinotropic actions of GLP-2 on the colon have been shown to be mediated through the actions of keratinocyte growth factor and insulin-like growth factor (IGF)-2, whereas small intestinal growth has been linked to IGF-1, IGF-2 and ErbB ligands, as well as the IGF-1 receptor and ErbB, respectively. The cellular source of these mediators remains unclear, but likely includes the intestinal subepithelial myofibroblasts. Conversely, the anti-inflammatory and blood flow effects of GLP-2 are dependent upon vasoactive intestinal polypeptide released from submucosal enteric neurons and nitric oxide, respectively. Finally, recent studies have suggested that GLP-2 not only modulates intestinal stem cell behavior, but may also promote carcinogenesis in models of sporadic colon cancer. Further consideration of the molecular cross-talk and downstream signaling pathways mediating the intestinotropic effects of GLP-2 is clearly warranted. |
| | |
Authors:
|
Katherine J Rowland; Patricia L Brubaker |
Related Documents
:
|
16537077 - Distribution and roles of aquaporins in salivary glands. 21361997 - The host selects mucosal and luminal associations of co-evolved gut microbes: a novel c... 20226247 - Hsp65 serves as an immunogenic carrier for a diabetogenic peptide p277 inducing anti-in... 18083577 - Entry route of salmonella typhimurium directs the type of induced immune response. 18005747 - How viruses avoid stress. 15814127 - The quantification of cellular viability and inflammatory response to stainless steel a... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-28 |
Journal Detail:
|
Title: American journal of physiology. Gastrointestinal and liver physiology Volume: - ISSN: 1522-1547 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1University of Toronto. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A role for transcription factor E2F2 in hepatocyte proliferation and timely liver regeneration.
Next Document: SREBP2 mediates the modulation of Intestinal NPC1L1 Expression by Curcumin.