Document Detail

The cryoglobulinemic vasculitis.
MedLine Citation:
PMID:  3787094     Owner:  NLM     Status:  MEDLINE    
Thirty-eight patients with essential mixed cryoglobulinemia (EMC: 16 type II and 22 type III) were evaluated. Almost all patients had clinical manifestations which could be related to a cutaneous and/or visceral vasculitic process. No significant clinical or laboratory differences were found between type II and type III EMC patients. Kidney biopsy performed in 9 patients showed membranoproliferative glomerulonephritis in 6 cases, diffuse proliferative glomerulonephritis in 2 cases and mesangioproliferative glomerulonephritis in one case. Skin biopsy performed in 11 patients showed typical leukocytoclastic vasculitis as the most common finding. A picture consistent with overlapping vasculitis was found in 2 cases (one type II and one type III) and thrombus-like deposits were observed in 3 cases (2 type II and one type III). These thrombotic lesions, not associated with vessel wall necrosis and inflammatory infiltrate, were indistinguishable from those observed in one case of type I cryoglobulinemia. Our data emphasize the complexity of blood vessel involvement in cryoglobulinemia and point out the possible existence of multiple pathogenetic mechanisms.
R Cattaneo; M G Fenini; F Facchetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  La Ricerca in clinica e in laboratorio     Volume:  16     ISSN:  0390-5748     ISO Abbreviation:  Ric Clin Lab     Publication Date:    1986 Apr-Jun
Date Detail:
Created Date:  1987-01-07     Completed Date:  1987-01-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7613947     Medline TA:  Ric Clin Lab     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  327-33     Citation Subset:  IM    
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MeSH Terms
Capillaries / pathology
Cryoglobulinemia / classification,  complications*,  diagnosis
Cryoglobulins / analysis
Kidney / pathology
Kidney Diseases / etiology
Skin / blood supply,  pathology
Vasculitis / blood,  complications*,  diagnosis
Reg. No./Substance:

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