Document Detail

The cryobiological basis for cryosurgery.
MedLine Citation:
PMID:  893760     Owner:  NLM     Status:  MEDLINE    
This paper discusses two important biological factors contributing to the death of cells within any region that is frozen cryosurgically. The first factor is the relationship between cell death and the thermal history experienced by each cell. Freezing with a single probe as usually done cannot provide sufficiently uniform conditions of cooling and warming to ensure widespread cell death. This situation can be improved by cycling a single probe at subzero temperatures or by the use of a multiple probe. The second factor is that of possible immunological responses induced by cryosurgical freezing. Improvements in understanding of biological implications of low temperatures in cryosurgery will aid the practical usefulness of these techniques.
J Farrant; C A Walter
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of dermatologic surgery and oncology     Volume:  3     ISSN:  0148-0812     ISO Abbreviation:  J Dermatol Surg Oncol     Publication Date:    1977 Jul-Aug
Date Detail:
Created Date:  1977-10-20     Completed Date:  1977-10-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7707501     Medline TA:  J Dermatol Surg Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  403-7     Citation Subset:  IM    
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MeSH Terms
Cell Survival*
Cryosurgery* / methods
Intracellular Fluid
Time Factors
Reg. No./Substance:
0/Antigens; 0/Sulfoxides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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