Document Detail

A crucial role of L-selectin in C protein-induced experimental polymyositis in mice.
MedLine Citation:
PMID:  24644046     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the role of adhesion molecules in C protein-induced myositis (CIM), a murine model of polymyositis (PM).
METHODS: CIM was induced in wild-type mice, L-selectin-deficient (L-selectin(-/-) ) mice, intercellular adhesion molecule 1 (ICAM-1)-deficient (ICAM-1(-/-) ) mice, and mice deficient in both L-selectin and ICAM-1 (L-selectin(-/-) ICAM-1(-/-) mice). Myositis severity, inflammatory cell infiltration, and messenger RNA expression in the inflamed muscles were analyzed. The effect of dendritic polyglycerol sulfate, a synthetic inhibitor that suppresses the function of L-selectin and endothelial P-selectin, was also examined.
RESULTS: L-selectin(-/-) mice and L-selectin(-/-) ICAM-1(-/-) mice developed significantly less severe myositis compared to wild-type mice, while ICAM-1 deficiency did not inhibit the development of myositis. L-selectin(-/-) mice that received wild-type T cells developed myositis. Treatment with dendritic polyglycerol sulfate significantly diminished the severity of myositis in wild-type mice compared to treatment with control.
CONCLUSION: These data indicate that L-selectin plays a major role in the development of CIM, whereas ICAM-1 plays a lesser role, if any, in the development of CIM. L-selectin-targeted therapy may be a candidate for the treatment of PM.
Kyosuke Oishi; Yasuhito Hamaguchi; Takashi Matsushita; Minoru Hasegawa; Naoko Okiyama; Jens Dernedde; Marie Weinhart; Rainer Haag; Thomas F Tedder; Kazuhiko Takehara; Hitoshi Kohsaka; Manabu Fujimoto
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis & rheumatology (Hoboken, N.J.)     Volume:  66     ISSN:  2326-5205     ISO Abbreviation:  -     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-06-30     Completed Date:  2014-09-09     Revised Date:  2014-11-12    
Medline Journal Info:
Nlm Unique ID:  101623795     Medline TA:  Arthritis Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1864-71     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2014 by the American College of Rheumatology.
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MeSH Terms
Adjuvants, Immunologic / pharmacology
Adoptive Transfer
CD8-Positive T-Lymphocytes / immunology
Carrier Proteins / pharmacology*
Cell Movement / immunology
Disease Models, Animal
Freund's Adjuvant / pharmacology
Glycerol / pharmacology
Intercellular Adhesion Molecule-1 / genetics,  immunology*
L-Selectin / genetics,  immunology*
Mice, Inbred C57BL
Mice, Knockout
Polymers / pharmacology
Polymyositis / chemically induced,  genetics,  immunology*
Severity of Illness Index
Grant Support
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Carrier Proteins; 0/Icam1 protein, mouse; 0/Polymers; 0/myosin-binding protein C; 126547-89-5/Intercellular Adhesion Molecule-1; 126880-86-2/L-Selectin; 25618-55-7/polyglycerol; 9007-81-2/Freund's Adjuvant; PDC6A3C0OX/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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