| The crucial role of the Aspergillus fumigatus siderophore system in interaction with alveolar macrophages. | |
| | |
MedLine Citation:
|
PMID: 20659583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Iron plays a central role in manifestation of infections for a variety of pathogens. To ensure an adequate supply with iron, Aspergillus fumigatus employs extra- and intracellular siderophores (low-molecular mass iron chelators), which are of importance for fungal growth in particular during iron starvation. Here we show that the lack of extracellular siderophores, and especially, the lack of the entire siderophore system cause in immunosuppressed mice in vivo (i) a reduced extracellular growth rate, (ii) a reduced intracellular growth rate in alveolar macrophages, and (iii) an increased susceptibility to conidial growth inhibition by alveolar macrophages. These data underline the crucial role of the fungal siderophore system not only for extracellular growth but also in the interaction with the host immune cells. Moreover, the hyphal growth rate within alveolar macrophages compared to extracellular lavage fluid was significantly decreased indicating that, besides elimination of fungal conidia, inhibition of pathogenic growth is a function of macrophages. |
| | |
Authors:
|
Markus Schrettl; Oumaima Ibrahim-Granet; Sabrina Droin; Michel Huerre; Jean-Paul Latgé; Hubertus Haas |
Related Documents
:
|
6966893 - Alveolar response to experimental pneumocystis carinii pneumonia in the rat. 1192853 - Depressant effect of marihuana smoke on antibactericidal activity of pulmonary alveolar... 21753853 - Tumour hypoxia promotes tolerance and angiogenesis via ccl28 and t(reg) cells. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-24 |
Journal Detail:
|
Title: Microbes and infection / Institut Pasteur Volume: 12 ISSN: 1769-714X ISO Abbreviation: Microbes Infect. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-25 Completed Date: 2011-01-31 Revised Date: 2011-04-06 |
Medline Journal Info:
|
Nlm Unique ID: 100883508 Medline TA: Microbes Infect Country: France |
Other Details:
|
Languages: eng Pagination: 1035-41 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved. |
Affiliation:
|
Division of Molecular Biology/Biocenter, Innsbruck Medical University, Fritz-Pregl-Str. 3, 6020 Innsbruck, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aspergillosis / microbiology* Aspergillus fumigatus / immunology*, pathogenicity* Histocytochemistry Host-Pathogen Interactions* Humans Hyphae / growth & development Inflammation / pathology Lung / microbiology, pathology Macrophages, Alveolar / immunology*, microbiology* Male Mice Microscopy Siderophores / metabolism* Virulence Virulence Factors / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
P 21643-B11//Austrian Science Fund FWF |
| Chemical | |
Reg. No./Substance:
|
0/Siderophores; 0/Virulence Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Human transcriptome analysis reveals a potential role for active transport in the metabolism of Pseu...
Next Document: Prevention by L-carnitine of DNA damage induced by propionic and L-methylmalonic acids in human peri...