Document Detail

The crossover experiment for clinical trials.
MedLine Citation:
PMID:  7370374     Owner:  NLM     Status:  MEDLINE    
The two-period crossover or changeover design for clinical trials is compared with other simple designs in terms of statistical precision and cost. The sensitivity of the crossover to bias due to carryover effects is examined. The feasibility of using the crossover data to test for the existence of carryover effects is investigated and found to be uneconomical. A numerical example is presented.
B W Brown
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biometrics     Volume:  36     ISSN:  0006-341X     ISO Abbreviation:  Biometrics     Publication Date:  1980 Mar 
Date Detail:
Created Date:  1980-07-12     Completed Date:  1980-07-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370625     Medline TA:  Biometrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  69-79     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic / economics,  methods*
Random Allocation
Research Design*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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