| The crossover design to evaluate the efficacy of plaque removal in tooth-brushing studies. | |
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MedLine Citation:
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PMID: 16212577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate the crossover clinical trial design to assess plaque removal efficacy of the Sonicare Elite. MATERIAL AND METHODS: A single-cohort, 12-week, two-treatment, single-blind, crossover clinical trial recruited 45 subjects. Plaque was recorded using the modified Quigley and Hein index plaque index (PI). After screening, subjects used the toothbrush for 2 weeks and were reminded to abstain from tooth cleaning 12-18 h prior to appointments. At visit two, subjects were randomized to 2 or 2(1/2) min. brushing time. PIs was recorded pre- and post-brushing. Subjects brushed for the allocated time for a further 2 weeks. At visit 3, PIs were recorded pre- and post-brushing. Two weeks later, at visit 4, the subjects crossed over and the protocol was repeated. RESULTS: There was no evidence of a learning effect within each arm of the crossover. A significant period effect was detected; however, no significant treatment by period effect was found. 2(1/2) min. brushing removed more plaque at full mouth (p=0.037), smooth (p=0.012) and lingual (p=0.002) sites compared with 2 min. CONCLUSION: The crossover design is a valid model for assessing plaque removal efficacy in tooth-brushing studies where no carry-over effect is clinically plausible. |
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Authors:
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G I McCracken; N Steen; P M Preshaw; L Heasman; F Stacey; P A Heasman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: Journal of clinical periodontology Volume: 32 ISSN: 0303-6979 ISO Abbreviation: J. Clin. Periodontol. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-10 Completed Date: 2005-12-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425123 Medline TA: J Clin Periodontol Country: Denmark |
Other Details:
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Languages: eng Pagination: 1157-62 Citation Subset: D; IM |
Copyright Information:
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Copyright (c) Blackwell Munksgaard, 2005. |
Affiliation:
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School of Dental Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK. g.i.mccracken@newcastle.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Analysis of Variance Cross-Over Studies Dental Plaque / therapy* Dental Plaque Index Humans Middle Aged Single-Blind Method Time Factors Toothbrushing / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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