Document Detail


A cross-sectional study of osteocalcin and body fat measures among obese adolescents.
MedLine Citation:
PMID:  23712984     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the relationships of OCN to body fat measures and whether they vary according to markers of energy and vitamin D metabolism.
DESIGN AND METHODS: Data were obtained from 58 obese adolescents aged 13-17.9 years (38 females, 8 black or African-American). Total fat mass (FM) [dual X-ray absorptiometry (DXA)] and visceral adipose tissue (VAT) [computerized axial tomography (CT)] were calculated. Blood tests included leptin, OCN, 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), thyroid function tests, and triglycerides. Markers of glucose metabolism were obtained from fasting and OGTT samples.
RESULTS AND CONCLUSIONS: Adolescents with 25(OH)D <20 ng mL(-1) were considered deficient (n = 17/58); none had high PTH (PTH ≥ 65 pg mL(-1) ). OCN was associated with lower VAT (-84.27 ± 33.89 mm(2) ) and BMI (-0.10 ± 0.05 kg m(-2) ), not FM (P = 0.597) in a core model including age, sex, race, geographic latitude, summer, height z-score, and tanner stage. Adding 25(OH)D deficiency and PTH attenuated the inverse association of OCN to VAT. There was a significant interaction of OCN and 25(OH)D deficiency on FM (0.37 ± 0.18 kg, P = 0.041) and BMI (0.28 ± 0.10 kg m(-2) , P = 0.007) in this adjusted model, which was further explained by leptin. Adding A1C to the core model modified the relationship of OCN to VAT (-93.08 ± 35.05 mm(2) , P = 0.011), which was further explained by HOMA-IR. In summary, these findings provide initial evidence for a relationship between OCN and body fat measures that is dependent on energy metabolism and vitamin D status among obese adolescents.
Authors:
Carine M Lenders; Phillip D K Lee; Henry A Feldman; Darrell M Wilson; Stephanie H Abrams; Stephen E Gitelman; William J Klish; Marcia S Wertz; George A Taylor; Richard T Alongi; Tai C Chen; Michael F Holick;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  21     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-05-28     Completed Date:  2014-01-17     Revised Date:  2014-02-14    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  808-14     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 The Obesity Society.
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Adipose Tissue / chemistry*
Adolescent
African Americans
Body Mass Index
Cross-Sectional Studies
Female
Humans
Intra-Abdominal Fat / chemistry
Leptin / blood
Male
Obesity / blood*
Osteocalcin / blood*
Parathyroid Hormone / blood
Vitamin D / blood
Grant Support
ID/Acronym/Agency:
K24 HD042489/HD/NICHD NIH HHS; MO1-RR00070/RR/NCRR NIH HHS; MO1-RR00188/RR/NCRR NIH HHS; MO1-RR00533/RR/NCRR NIH HHS; MO1-RR00865/RR/NCRR NIH HHS; MO1-RR02172/RR/NCRR NIH HHS; P30 DK063720/DK/NIDDK NIH HHS; UL-RR024131-01/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Leptin; 0/Parathyroid Hormone; 104982-03-8/Osteocalcin; 1406-16-2/Vitamin D
Investigator
Investigator/Affiliation:
Darrell M Wilson / ; Patricia Fechner / ; Tandy Aye / ; Thomas Robinson / ; Bruce Buckingham / ; Trudy Esrey / ; Keniki McNeil / ; Beatrice Sorensen / ; Kirsten Wilson / ; Jeanne Davis / ; William Klish / ; Stephanie Abrams / ; Pam Holt / ; Cynthia Edwards / ; Linda Howard / ; Stephen Gitelman / ; Robert Lustig / ; Marcia Wertz / ; Jessica Breland / ; Tania Lihatsh / ; Phillip D K Lee / ; Anna Haddal / ; Pinchas Cohen / ; Sally Shupien / ; Janet Mooney / ; Elena Khanukhova / ; Helene Cohen / ; Carine Lenders / ; George Taylor / ; Christopher Duggan / ; Sam Nurko / ; Carol Sweeney / ; Katie Zhang / ; Stavroula Osganian / ; Henry Feldman / ; Maggie McCarthy / ; Michael Wake / ; Rajna Filip-Dhima / ; Charles Prober / ; Karen Urbanek / ; Alisa Kim / ; Anita Kelley / ; Christine Crabtree / ; Dennis Styne / ; Michael Gottschalk / ; Daniel Hale / ; Heidi Krause-Steinrauf /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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