Document Detail


A cross-sectional study of exercise performance during the first 2 decades of life after the Fontan operation.
MedLine Citation:
PMID:  18598887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of this study was to describe exercise performance during the first 2 decades of life in Fontan survivors by a cross-sectional study and to identify factors that influence exercise performance. BACKGROUND: Exercise performance after the Fontan procedure is reduced relative to performance in healthy subjects. Data on pre-adolescents are limited, and the patterns of exercise performance in different ages are unexplored. METHODS: Ramp cycle ergometry was performed with expired gas. Data were analyzed for the entire study population and for subpopulations that did and did not achieve a maximal aerobic capacity. RESULTS: Of 411 subjects tested (12.4 +/- 3.2 years of age), 166 achieved a maximal aerobic capacity. Peak oxygen consumption (VO(2)) was 26.3 ml/kg/min (65% of predicted for age and gender [% predicted]) for the entire population and was lower in the submaximal capacity subgroup compared with the maximal capacity subgroup (63% predicted and 67% predicted, respectively; p = 0.02). Oxygen consumption at ventilatory anaerobic threshold (VAT) was better preserved (78% predicted for the total population) than peak VO(2). Higher % predicted O(2) pulse at peak exercise was associated with greater % predicted peak VO(2), work rate, and VAT. Adolescence and male gender were associated with decreased % predicted peak VO(2). The relationship between echocardiographic indexes of ventricular function and exercise function was surprisingly weak. CONCLUSIONS: In Fontan patients, maximal aerobic capacity is reduced compared with healthy subjects, with better preservation of submaximal performance. Higher O(2) pulse is associated with better exercise performance, whereas adolescence and male gender are associated with decreased performance compared with healthy subjects.
Authors:
Stephen M Paridon; Paul D Mitchell; Steven D Colan; Richard V Williams; Andrew Blaufox; Jennifer S Li; Renee Margossian; Seema Mital; Jennifer Russell; Jonathan Rhodes;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  52     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-07     Completed Date:  2008-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-107     Citation Subset:  AIM; IM    
Affiliation:
The University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. Paridon@email.chop.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Cross-Sectional Studies
Exercise / physiology*
Exercise Test
Female
Fontan Procedure*
Heart Defects, Congenital / physiopathology,  surgery*
Heart Rate / physiology
Humans
Infant
Lung / physiology
Male
Oxygen Consumption / physiology
Treatment Outcome
Grant Support
ID/Acronym/Agency:
U01 HL068290/HL/NHLBI NIH HHS; U01-HL068269/HL/NHLBI NIH HHS; U01-HL068270/HL/NHLBI NIH HHS; U01-HL068279/HL/NHLBI NIH HHS; U01-HL068281/HL/NHLBI NIH HHS; U01-HL068285/HL/NHLBI NIH HHS; U01-HL068288/HL/NHLBI NIH HHS; U01-HL068292/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
J Am Coll Cardiol. 2008 Jul 8;52(2):114-6   [PMID:  18598889 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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