| A cross-sectional study evaluating chemiluminescence and autofluorescence in the detection of clinically innocuous precancerous and cancerous oral lesions. | |
| | |
MedLine Citation:
|
PMID: 20123872 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: ViziLite Plus with TBlue system (Zila Pharmaceuticals; now Zila, a division of Tolmar, Fort Collins, Colo.) and VELscope (LED Dental, White Rock, British Columbia, Canada) are oral cancer screening aids that have been developed to assist dentists in identifying precancerous and cancerous oral lesions. METHODS: The authors screened patients with an overhead examination light and then with VELscope or ViziLite. Patients with a clinically innocuous lesion underwent a biopsy, and the authors compared the results of tissue pathological analysis with findings from the screening aid tests to determine the sensitivity and specificity of each device. The authors tested these devices to determine their ability to aid in the decision-making process regarding whether further evaluation of a clinically innocuous lesion was required. RESULTS: The authors examined 102 lesions with ViziLite and then biopsied them [corrected]. They found three dysplasias and one malignancy, none of which were detected with the ViziLite (sensitivity = 0 percent, confidence interval [CI] = 0-60.2 percent; specificity = 75.5 percent, CI = 66.7-82.8 percent). The authors examined another 156 lesions with VELscope and then biopsied them [corrected].They found 11 dysplasias and one malignancy, six of which were detected with VELscope (sensitivity = 50 percent, CI = 21.1-78.9 percent; specificity = 38.9 percent, CI = 30.8-46.9 percent). CONCLUSIONS: The study results indicate that use of ViziLite or VELscope along with a conventional screening examination for lesions deemed clinically innocuous was not beneficial in identifying dysplasia or cancer. Additional clinical studies are needed before these devices can be recommended. CLINICAL IMPLICATIONS: Clinicians and patients could have a false sense of security after obtaining a negative ViziLite or VELscope examination result because potentially large numbers of precancerous and cancerous lesions will be missed by both devices. |
| | |
Authors:
|
Ravi Mehrotra; Mamta Singh; Shaji Thomas; Preeti Nair; Shruti Pandya; Niraj Shakti Nigam; Pankaj Shukla |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Journal of the American Dental Association (1939) Volume: 141 ISSN: 1943-4723 ISO Abbreviation: J Am Dent Assoc Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-02-03 Completed Date: 2010-05-18 Revised Date: 2010-06-04 |
Medline Journal Info:
|
Nlm Unique ID: 7503060 Medline TA: J Am Dent Assoc Country: United States |
Other Details:
|
Languages: eng Pagination: 151-6 Citation Subset: D; IM |
Affiliation:
|
Department of Pathology, Moti Lal Nehru Medical College, Lowther Road, Allahabad 211 001, India. rm8509@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetic Acid
/
diagnostic use Adult Biopsy / standards Carcinoma / diagnosis Chemiluminescent Measurements / instrumentation*, standards Coloring Agents / diagnostic use Cross-Sectional Studies Equipment Design Female Fluorescence Humans Indicators and Reagents Luminescent Measurements / instrumentation*, standards Male Mass Screening / instrumentation*, standards Mouth Neoplasms / diagnosis* Precancerous Conditions / diagnosis* Predictive Value of Tests Sensitivity and Specificity Tolonium Chloride / diagnostic use |
| Chemical | |
Reg. No./Substance:
|
0/Coloring Agents; 0/Indicators and Reagents; 64-19-7/Acetic Acid; 92-31-9/Tolonium Chloride |
| Comments/Corrections | |
Comment In:
|
J Am Dent Assoc. 2010 Jun;141(6):626, 628; author reply 628, 630
[PMID:
20516088
]
J Am Dent Assoc. 2010 Jun;141(6):626; author reply 628, 630 [PMID: 20516089 ] |
Erratum In:
|
J Am Dent Assoc. 2010 Apr;141(4):388 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Is income inequality related to childhood dental caries in rich countries?
Next Document: The Effect of Er,Cr:YSGG Laser and Air Abrasion on Shear Bond Strength of a Fissure Sealant to Ename...