| A cross-sectional study contrasting olfactory function in autonomic disorders. | |
| | |
MedLine Citation:
|
PMID: 21282592 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To compare odor identification function in patients with peripheral or central autonomic neurodegeneration and in patients with intact autonomic neurons but undetectable norepinephrine. METHODS: Olfactory function was evaluated with the University of Pennsylvania Smell Identification Test (UPSIT) in 12 patients with pure autonomic failure, 10 patients with multiple system atrophy, and 4 patients with dopamine β-hydroxylase deficiency. Blood pressure and catecholamine data were also compared. RESULTS: Odor identification was significantly impaired in patients with pure autonomic failure relative to patients with multiple system atrophy or dopamine β-hydroxylase deficiency. Out of 40 odors, the patients correctly identified mean (95% confidence interval) 19.2 (14.1 to 24.2), 34.4 (32.2 to 36.6), and 31.7 (29.4 to 34.1) (p < 0.001). The difference between patients with pure autonomic failure and those with multiple system atrophy or dopamine β-hydroxylase deficiency persisted after adjustment for age (p = 0.001). Patients with pure autonomic failure also had a greater orthostatic fall in blood pressure and lower plasma norepinephrine levels than patients with multiple system atrophy. CONCLUSIONS: Olfactory function was relatively intact in patients with dopamine β-hydroxylase deficiency, who have intact noradrenergic neurons but lack norepinephrine. Odor identification was impaired in pure autonomic failure but not in multiple system atrophy, suggesting that 1) peripheral noradrenergic innervation is important for olfactory identification but norepinephrine is not essential and 2) UPSIT may be useful in the differential diagnosis between these disorders. |
| | |
Authors:
|
E M Garland; S R Raj; A C Peltier; D Robertson; I Biaggioni |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neurology Volume: 76 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-01 Completed Date: 2011-03-28 Revised Date: 2012-02-01 |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
|
Languages: eng Pagination: 456-60 Citation Subset: AIM; IM |
Affiliation:
|
Autonomic Dysfunction Center, AA3228 Medical Center North, Vanderbilt University, Nashville, TN 37232-2195, USA. emily.garland@vanderbilt.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Autonomic Nervous System Diseases / complications*, diagnosis, physiopathology* Cross-Sectional Studies Diagnosis, Differential Female Humans Male Middle Aged Multiple System Atrophy / complications, diagnosis, physiopathology Neurologic Examination / methods Olfaction Disorders / complications*, diagnosis, physiopathology* Physical Examination / methods Predictive Value of Tests Pure Autonomic Failure / complications, diagnosis, physiopathology Smell / genetics, physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
P01 HL56693/HL/NHLBI NIH HHS; R01 HL071784/HL/NHLBI NIH HHS; R01 NS055670/NS/NINDS NIH HHS; UL1 RR024975/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A novel clinical syndrome revealing a deficiency of the muscarinic M3 receptor.
Next Document: A retrospective review of X-linked Charcot-Marie-Tooth disease in childhood.