| Cross-sectional and longitudinal association of serum alanine aminotransaminase and γ-glutamyltransferase with metabolic syndrome in middle-aged and elderly Chinese people. | |
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MedLine Citation:
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PMID: 21199427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although associations of the liver enzymes alanine aminotransaminase (ALT) and γ-glutamyltransferase (GGT) with metabolic syndrome (MetS) are well recognized, whether they are independent of insulin resistance and which enzyme is more effective are yet to be clarified. METHODS: A total of 5404 subjects aged ≥ 40 years were recruited from two urban communities in Shanghai for cross-sectional analyses. A subgroup of 681 participants without MetS at baseline was included in the longitudinal analyses. Insulin resistance was measured using the homeostasis model assessment of insulin resistance (HOMA-IR), and the modified National Cholesterol Education Program Adult Treatment Panel III criteria were adopted to diagnose MetS. RESULTS: Both GGT and ALT were strongly and positively associated with MetS risks in simple and multivariate analyses. Further adjustment for HOMA-IR and ALT did not change the association of GGT and MetS materially, whereas adjustment for HOMA-IR and GGT substantially attenuated the ALT-MetS association. In longitudinal analyses, risks of developing MetS were increased across GGT quartiles in a dose-dependent manner after extensive adjustments (odds ratios were 1.00, 1.38, 1.62, and 2.29 for GGT, quartile 1 through quartile 4; P for trend = 0.01). In contrast, ALT was no longer associated with MetS development after final adjustment for GGT (P for trend = 0.09). CONCLUSIONS: Our study confirmed significant and independent associations of GGT and ALT with MetS in adult Chinese people. Moreover, GGT might be more effective for indicating the future development of MetS. |
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Authors:
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Yu Xu; Yu-fang Bi; Min Xu; Yun Huang; Wen-ying Lu; Yi-fu Gu; Guang Ning; Xiao-ying Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of diabetes Volume: 3 ISSN: 1753-0407 ISO Abbreviation: J Diabetes Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-21 Completed Date: 2011-07-22 Revised Date: 2011-09-27 |
Medline Journal Info:
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Nlm Unique ID: 101504326 Medline TA: J Diabetes Country: Australia |
Other Details:
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Languages: eng Pagination: 38-47 Citation Subset: IM |
Copyright Information:
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© 2011 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, The State Key Laboratory of Medical Genomics, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alanine Transaminase / blood* Asian Continental Ancestry Group Blood Glucose / metabolism Body Mass Index China Cross-Sectional Studies Homeostasis Humans Insulin / blood Insulin Resistance* Lipoproteins, HDL / blood Longitudinal Studies Metabolic Syndrome X / blood, enzymology*, ethnology Middle Aged Multivariate Analysis Odds Ratio Risk Factors gamma-Glutamyltransferase / blood* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Lipoproteins, HDL; 11061-68-0/Insulin; EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.2/Alanine Transaminase |
| Comments/Corrections | |
Comment In:
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J Diabetes. 2011 Sep;3(3):182-3
[PMID:
21631900
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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