| A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC). | |
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MedLine Citation:
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PMID: 20731527 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk. Aim: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3. Subjects and methods: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC). Results: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: - 0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m(2) had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all < 0.001). Conclusion: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers. |
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Authors:
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Francesca L Crowe; Timothy J Key; Naomi E Allen; Paul N Appleby; Kim Overvad; Henning Grønbæk; Anne Tjønneland; Jytte Halkjær; Laure Dossus; Heiner Boeing; Janine Kröger; Antonia Trichopoulou; Dimosthenis Zylis; Dimitrios Trichopoulos; Marie-Christine Boutron-Ruault; Blandine de Lauzon-Guillain; Françoise Clavel-Chapelon; Domenico Palli; Franco Berrino; Salvatore Panico; Rosario Tumino; Carlotta Sacerdote; H Bas Bueno-de-Mesquita; Carla H van Gils; Petra H M Peeters; Inger T Gram; Laudina Rodríguez; Paula Jakszyn; Esther Molina-Montes; Carmen Navarro; Aurelio Barricarte; Nerea Larrañaga; Kay-Tee Khaw; Sheila Rodwell; Sabina Rinaldi; Nadia Slimani; Teresa Norat; Valentina Gallo; Elio Riboli; Rudolf Kaaks |
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Publication Detail:
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Type: Journal Article Date: 2010-08-23 |
Journal Detail:
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Title: Annals of human biology Volume: 38 ISSN: 1464-5033 ISO Abbreviation: Ann. Hum. Biol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404024 Medline TA: Ann Hum Biol Country: England |
Other Details:
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Languages: eng Pagination: 194-202 Citation Subset: IM |
Affiliation:
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Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, OX3 7LF, UK. |
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