Document Detail


The cross-priming pathway: a portrait of an intricate immune system.
MedLine Citation:
PMID:  17386021     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antigen presentation by professional antigen-presenting cells (pAPCs) to cytotoxic CD8(+) T cells can occur via two processing routes - the direct and cross-presentation pathways. Cross-presentation of exogenous antigens in the context of major histocompatibility complex (MHC) class I molecules has recently attracted a lot of research interest because it may prove crucial for vaccine development. This alternative pathway has been implicated in priming CD8(+) T-cell responses to pathogens as well as tumours in vivo (cross-priming). In cross-presentation, the internalized antigens can be processed through diverse intracellular routes. As many unresolved questions regarding the molecular basis that controls the cross-priming process still exist, it is essential to explore the various elements involved therein, to better elucidate this pathway. In this review, we summarize current data that explore how the source and nature of antigens could affect their cross-presentation. Moreover, we will discuss and outline how recent advances regarding pAPCs' properties have increased our appreciation of the complex nature of the cross-priming pathway in vivo. In conclusion, we contemplate how the direct and cross-presentation pathways can function to allow the immune system to deal efficiently with diverse pathogens.
Authors:
S Basta; A Alatery
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  65     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-27     Completed Date:  2007-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  311-9     Citation Subset:  IM    
Affiliation:
Department of Microbiology & Immunology, Queen's University, Kingston, ON, Canada. bastas@post.queensu.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigen Presentation / immunology*
Antigen-Presenting Cells / immunology*
CD8-Positive T-Lymphocytes / immunology
Cross-Priming / immunology*
Histocompatibility Antigens Class I / immunology
Humans
Models, Immunological*
Chemical
Reg. No./Substance:
0/Histocompatibility Antigens Class I

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