| A cross-linking assay allows the detection of receptors for the somatostatin analogue, lanreotide in human breast tumours. | |
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MedLine Citation:
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PMID: 8105838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypothalamic somatostatin and its synthetic analogues inhibit the cell growth of several tumour models. The somatostatin analogue lanreotide (somatuline or BIM23014C) inhibits both the in vivo and in vitro cell growth of various mammary tumours. In order to evaluate the presence of receptors for lanreotide in breast tissue, samples from 41 female and 2 male patients were analysed by a cross-linking assay. All the samples examined possessed at least one subtype of lanreotide binding polypeptide, however, different polypeptide patterns were observed. The two major complexes had molecular weights of 57 kD and 42 kD. The previously demonstrated antiproliferative activity of lanreotide and the high percentage of positive tumours supports the use of lanreotide in clinical trials. However, the role of each receptor subtype in the control of breast cell proliferation requires further characterisation. |
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Authors:
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G Prévost; P Provost; V Sallé; M Lanson; F Thomas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of cancer (Oxford, England : 1990) Volume: 29A ISSN: 0959-8049 ISO Abbreviation: Eur. J. Cancer Publication Date: 1993 |
Date Detail:
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Created Date: 1993-12-09 Completed Date: 1993-12-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9005373 Medline TA: Eur J Cancer Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1589-92 Citation Subset: IM |
Affiliation:
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Institut d'Oncologie Cellulaire et Moléculaire Humaine, Université Paris-Nord, Bobigny, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antineoplastic Agents / metabolism* Breast Neoplasms / chemistry*, metabolism Female Humans Male Middle Aged Molecular Weight Oligopeptides / metabolism* Receptors, Estrogen / analysis Receptors, Progesterone / analysis Receptors, Somatostatin / analysis* Somatostatin / analogs & derivatives*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Oligopeptides; 0/Receptors, Estrogen; 0/Receptors, Progesterone; 0/Receptors, Somatostatin; 113294-82-9/angiopeptin; 51110-01-1/Somatostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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