Document Detail

A cross-linking assay allows the detection of receptors for the somatostatin analogue, lanreotide in human breast tumours.
MedLine Citation:
PMID:  8105838     Owner:  NLM     Status:  MEDLINE    
Hypothalamic somatostatin and its synthetic analogues inhibit the cell growth of several tumour models. The somatostatin analogue lanreotide (somatuline or BIM23014C) inhibits both the in vivo and in vitro cell growth of various mammary tumours. In order to evaluate the presence of receptors for lanreotide in breast tissue, samples from 41 female and 2 male patients were analysed by a cross-linking assay. All the samples examined possessed at least one subtype of lanreotide binding polypeptide, however, different polypeptide patterns were observed. The two major complexes had molecular weights of 57 kD and 42 kD. The previously demonstrated antiproliferative activity of lanreotide and the high percentage of positive tumours supports the use of lanreotide in clinical trials. However, the role of each receptor subtype in the control of breast cell proliferation requires further characterisation.
G Prévost; P Provost; V Sallé; M Lanson; F Thomas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  29A     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  1993  
Date Detail:
Created Date:  1993-12-09     Completed Date:  1993-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1589-92     Citation Subset:  IM    
Institut d'Oncologie Cellulaire et Moléculaire Humaine, Université Paris-Nord, Bobigny, France.
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MeSH Terms
Aged, 80 and over
Antineoplastic Agents / metabolism*
Breast Neoplasms / chemistry*,  metabolism
Middle Aged
Molecular Weight
Oligopeptides / metabolism*
Receptors, Estrogen / analysis
Receptors, Progesterone / analysis
Receptors, Somatostatin / analysis*
Somatostatin / analogs & derivatives*,  metabolism
Reg. No./Substance:
0/Antineoplastic Agents; 0/Oligopeptides; 0/Receptors, Estrogen; 0/Receptors, Progesterone; 0/Receptors, Somatostatin; 113294-82-9/angiopeptin; 51110-01-1/Somatostatin

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