Document Detail


A cross-linking assay allows the detection of receptors for the somatostatin analogue, lanreotide in human breast tumours.
MedLine Citation:
PMID:  8105838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypothalamic somatostatin and its synthetic analogues inhibit the cell growth of several tumour models. The somatostatin analogue lanreotide (somatuline or BIM23014C) inhibits both the in vivo and in vitro cell growth of various mammary tumours. In order to evaluate the presence of receptors for lanreotide in breast tissue, samples from 41 female and 2 male patients were analysed by a cross-linking assay. All the samples examined possessed at least one subtype of lanreotide binding polypeptide, however, different polypeptide patterns were observed. The two major complexes had molecular weights of 57 kD and 42 kD. The previously demonstrated antiproliferative activity of lanreotide and the high percentage of positive tumours supports the use of lanreotide in clinical trials. However, the role of each receptor subtype in the control of breast cell proliferation requires further characterisation.
Authors:
G Prévost; P Provost; V Sallé; M Lanson; F Thomas
Related Documents :
7627088 - Cervical lymph node metastasis: model for study of head/neck melanoma.
11468508 - Comparison of the lectin-binding pattern in different human melanoma cell lines.
722378 - Ultrastructure of n-diethylnitrosamine induced tumours in the nasal olfactory region of...
18071318 - In neuroblastic tumours, schwann cells do not harbour the genetic alterations of neurob...
17428068 - Temporal sequence of cell wall disassembly events in developing fruits. 2. analysis of ...
2360458 - An immunohistochemical study of calcitonin-containing cells in benign and malignant thy...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  29A     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  1993  
Date Detail:
Created Date:  1993-12-09     Completed Date:  1993-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1589-92     Citation Subset:  IM    
Affiliation:
Institut d'Oncologie Cellulaire et Moléculaire Humaine, Université Paris-Nord, Bobigny, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antineoplastic Agents / metabolism*
Breast Neoplasms / chemistry*,  metabolism
Female
Humans
Male
Middle Aged
Molecular Weight
Oligopeptides / metabolism*
Receptors, Estrogen / analysis
Receptors, Progesterone / analysis
Receptors, Somatostatin / analysis*
Somatostatin / analogs & derivatives*,  metabolism
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Oligopeptides; 0/Receptors, Estrogen; 0/Receptors, Progesterone; 0/Receptors, Somatostatin; 113294-82-9/angiopeptin; 51110-01-1/Somatostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Immunological reconstitution after high-dose chemotherapy and autologous blood stem cell transplanta...
Next Document:  HER-2 and INT-2 amplification estimated by quantitative PCR in paraffin-embedded ovarian cancer tiss...