| A critique of the overfill hypothesis of sodium and water retention in the nephrotic syndrome. | |
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MedLine Citation:
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PMID: 9573524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent reviews have claimed that the majority of patients with the nephrotic syndrome have plasma volume expansion (that is, they are overfilled). Here we attempt to re-establish balance to the debate on body fluid volume status in nephrotic patients by: (a) discussing the conflicting literature on plasma volume measurements in the nephrotic syndrome; (b) providing alternate explanations for data purporting to support an overfill hypothesis in the nephrotic syndrome; (c) emphasizing secondary neurohumoral responses that support underfilling at least as frequently as overfilling; and (d) emphasizing the clinical importance of fluid assessment in the individual patient with the nephrotic syndrome particularly in relation to diuretic use. |
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Authors:
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R W Schrier; R G Fassett |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Kidney international Volume: 53 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-06-30 Completed Date: 1998-06-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1111-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Colorado School of Medicine, Denver, USA. Pat.Knox@UCHSC.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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physiology Animals Arginine Vasopressin / physiology Disease Models, Animal Edema / etiology, physiopathology Humans Models, Biological* Nephrotic Syndrome / complications*, physiopathology Plasma Volume Renin-Angiotensin System / physiology Sodium / metabolism* Sympathetic Nervous System / physiopathology Water-Electrolyte Imbalance / etiology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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113-79-1/Arginine Vasopressin; 52-39-1/Aldosterone; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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