Document Detail

The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation.
MedLine Citation:
PMID:  22910358     Owner:  NLM     Status:  In-Data-Review    
Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size control, cell volume at Start displays great individual variability even under constant conditions. Here we show that cell size at Start is robustly set at a single-cell level by the volume growth rate in G1, which explains the observed variability. We find that this growth-rate-dependent sizer is intimately hardwired into the Start network and the Ydj1 chaperone is key for setting cell size as a function of the individual growth rate. Mathematical modelling and experimental data indicate that a growth-rate-dependent sizer is sufficient to ensure size homeostasis and, as a remarkable advantage over a rigid sizer mechanism, it reduces noise in G1 length and provides an immediate solution for size adaptation to external conditions at a population level.
Francisco Ferrezuelo; Neus Colomina; Alida Palmisano; Eloi Garí; Carme Gallego; Attila Csikász-Nagy; Martí Aldea
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature communications     Volume:  3     ISSN:  2041-1723     ISO Abbreviation:  Nat Commun     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528555     Medline TA:  Nat Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  1012     Citation Subset:  IM    
1] Department Ciències Mèdiques Bàsiques, IRBLleida-UdL, 25008 Lleida, Catalonia, Spain. [2].
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