| A critical role for UVRAG in apoptosis. | |
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MedLine Citation:
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PMID: 21606679 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Autophagy and apoptosis are tightly regulated biological processes that are crucial for cell growth, development and tissue homeostasis. UVRAG (UV radiation resistance-associated gene), a mammalian homolog of yeast Vps38, activates the Beclin 1/PtdIns3KC3 (class III phosphatidylinositol-3-kinase) complex, which promotes autophagosome formation. Moreover, UVRAG promotes autophagosome maturation by recruiting class C Vps complexes (HOPS complexes) and Rab7 of the late endosome. We found that UVRAG has anti-apoptotic activity during tumor therapy through interactions with Bax. UVRAG inhibits Bax translocation from the cytosol to mitochondria during chemotherapy- or UV irradiation-induced apoptosis of human tumor cells. Moreover, deletion of the UVRAG C2 domain abolishes Bax binding and anti-apoptotic activity. These results suggest that, in addition to its previously recognized pro-autophagy activity in response to starvation, UVRAG has cytoprotective functions in the cytosol that control the localization of Bax in tumor cells exposed to apoptotic: stimuli. |
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Authors:
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Xiaocheng Yin; Lizhi Cao; Yanhui Peng; Yanfang Tan; Min Xie; Rui Kang; Kristen M Livesey; Daolin Tang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-01 |
Journal Detail:
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Title: Autophagy Volume: 7 ISSN: 1554-8635 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-5-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics; The First Affiliated Hospital of Nanhua University; Hengyang, Hunan People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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