Document Detail

A critical assessment of the upper intake levels for infants and children.
MedLine Citation:
PMID:  16424135     Owner:  NLM     Status:  MEDLINE    
The dietary reference intake (DRI) committees of the Food and Nutrition Board of the Institute of Medicine were charged with establishing DRIs for all of the essential nutrients, including fat and energy. These reference values are quantitative estimates of the nutrient intakes to be used to plan and assess the diets of healthy people. The reference values include both recommended intakes and tolerable upper intake levels (ULs). The ULs are defined as "the highest level of daily nutrient intake that is likely to pose no risk of adverse health effects to almost all individuals in the general population." As intake increases above the UL, the risk of adverse effects increases. The term "tolerable intake" was chosen to avoid the implication of a possible beneficial effect. Instead, the term is intended to connote a level of intake that can, with a high probability, be tolerated biologically. Yet, with intakes above the ULs, the risk of adverse health effects increases. Thus, there is no obvious benefit for healthy individuals to consume quantities of nutrients above the UL.
Stanley Zlotkin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  136     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-20     Completed Date:  2006-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  502S-506S     Citation Subset:  IM    
Department of Paediatrics, Centre for International Health, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Child, Preschool
Folic Acid / pharmacology
Infant, Newborn
Nutrition Assessment
Nutrition Policy*
Vitamin A / pharmacology
Zinc / pharmacology
Reg. No./Substance:
11103-57-4/Vitamin A; 59-30-3/Folic Acid; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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