Document Detail

A critical appraisal of open- and closed-chest models of experimental myocardial ischemia.
MedLine Citation:
PMID:  19384314     Owner:  NLM     Status:  MEDLINE    
Myocardial ischemia is one of the most extensively studied topics in modern cardiovascular research. Early investigators first reported experimental myocardial ischemia (EMI) in 1862. The open-chest (surgical) approach is a well-developed model of EMI that enables researchers to directly access and observe the heart. With this approach, EMI is generally induced by surgical ligation of a coronary artery. A drawback of the open-chest model is the need for major surgery, which can result in local and systemic side effects. Alternative closed-chest models of EMI have been developed; most of these models involve endovascular catheterization with coronary artery embolization or thrombosis. Closed-chest techniques eliminate the need for invasive surgery, and the resultant model is more physiologically similar to clinical myocardial ischemia than is EMI produced by artery ligation. The authors present a review of open- and closed-chest models of EMI and discuss the advantages and disadvantages of each approach.
Sofoklis Mitsos; Konstantinos Katsanos; Eftichia Dougeni; Efstratios N Koletsis; Dimitrios Dougenis
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Lab animal     Volume:  38     ISSN:  0093-7355     ISO Abbreviation:  Lab Anim (NY)     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-22     Completed Date:  2009-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417737     Medline TA:  Lab Anim (NY)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  167-77     Citation Subset:  IM    
Department of Cardiothoracic Surgery, University of Patras, School of Medicine, Rion, Greece.
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MeSH Terms
Animals, Laboratory
Coronary Vessels / surgery
Disease Models, Animal*
Heart Catheterization
Myocardial Ischemia / etiology*,  pathology,  physiopathology
Postoperative Complications
Surgical Procedures, Minimally Invasive / methods*
Thoracic Surgical Procedures / methods*

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