| A critical appraisal of open- and closed-chest models of experimental myocardial ischemia. | |
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MedLine Citation:
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PMID: 19384314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myocardial ischemia is one of the most extensively studied topics in modern cardiovascular research. Early investigators first reported experimental myocardial ischemia (EMI) in 1862. The open-chest (surgical) approach is a well-developed model of EMI that enables researchers to directly access and observe the heart. With this approach, EMI is generally induced by surgical ligation of a coronary artery. A drawback of the open-chest model is the need for major surgery, which can result in local and systemic side effects. Alternative closed-chest models of EMI have been developed; most of these models involve endovascular catheterization with coronary artery embolization or thrombosis. Closed-chest techniques eliminate the need for invasive surgery, and the resultant model is more physiologically similar to clinical myocardial ischemia than is EMI produced by artery ligation. The authors present a review of open- and closed-chest models of EMI and discuss the advantages and disadvantages of each approach. |
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Authors:
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Sofoklis Mitsos; Konstantinos Katsanos; Eftichia Dougeni; Efstratios N Koletsis; Dimitrios Dougenis |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Lab animal Volume: 38 ISSN: 0093-7355 ISO Abbreviation: Lab Anim (NY) Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-22 Completed Date: 2009-06-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417737 Medline TA: Lab Anim (NY) Country: United States |
Other Details:
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Languages: eng Pagination: 167-77 Citation Subset: IM |
Affiliation:
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Department of Cardiothoracic Surgery, University of Patras, School of Medicine, Rion, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Laboratory Coronary Vessels / surgery Disease Models, Animal* Embolism Heart Catheterization Ligation Microspheres Myocardial Ischemia / etiology*, pathology, physiopathology Postoperative Complications Surgical Procedures, Minimally Invasive / methods* Thoracic Surgical Procedures / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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