Document Detail

A critical analysis of the view that right atrial pressure determines venous return.
MedLine Citation:
PMID:  12391065     Owner:  NLM     Status:  MEDLINE    
A. C. Guyton pioneered major advances in understanding cardiovascular equilibrium. He superimposed venous return curves on cardiac output curves to reveal their intersection at the one level of right atrial pressure (Pra) and flow simultaneously consistent with independent properties of the heart and vasculature. He showed how this point would change with altered properties of the heart (e.g., contractility, sensitivity to preload) and/or of the vasculature (e.g., resistance, total volume). In such graphical representations of negative feedback between two subdivisions of a system, one input/output relationship is necessarily plotted backward, i.e., with the input variable on the y-axis (here, the venous return curve). Unfortunately, this format encourages mistaken ideas about the role of Pra as a "back pressure," such as the assertion that elevating Pra to the level of mean systemic pressure would stop venous return. These concepts are reexamined through review of the original experiments on venous return, presentation of a hypothetical alternative way for obtaining the same data, and analysis of a simple model.
George L Brengelmann
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Publication Detail:
Type:  Journal Article; Review     Date:  2002-10-18
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  94     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-06     Completed Date:  2003-09-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  849-59     Citation Subset:  IM    
Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195-7290, USA.
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MeSH Terms
Atrial Function, Right / physiology*
Blood Circulation / physiology*
Blood Pressure / physiology*
Cardiac Output / physiology
Models, Biological
Regional Blood Flow / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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