Document Detail

On the course of seropositive rheumatoid arthritis during and after long-term gold therapy.
MedLine Citation:
PMID:  7973474     Owner:  NLM     Status:  MEDLINE    
The purpose of the present study was to get an estimate on the course of seropositive RA in 93 patients, who had been in chrysotherapy for at least 3 years up to 13 years. The study was observational with assessment once a year by the same physician. After one year the median number of swollen joints had decreased from six to two (p = 0.0001), and the median number of tender joints from five to two (p = 0.0001). This improvement was maintained throughout the period. A decrease in median erythrocyte sedimentation rate from 34 mm/h to 15 mm/h remained significant for 10 years, although the ESR gradually increased throughout the period. An increase in median hemoglobin from 7.8 mmol/l to 8.5 mmol/l lasted for 7 years. Contrastingly, the number of joints with limited motion increased from a median score of 4 to a median score of 20 (p = 0.0001). Radiographical changes progressed from a median score of 18 to a median score of 84 (p = 0.0001). Significant correlations were found between the ESR, joint tenderness score and limitation of motion score at the year 1, and later progression of limitation of motion score, but too weak to be of predictive importance. In conclusion early symptomatic improvement of rheumatoid arthritis during gold treatment can be stable during several years, but progression in the number of joints with limited motion and radiographical changes continues.
H K Graudal; N Graudal; A G Jurik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of rheumatology     Volume:  23     ISSN:  0300-9742     ISO Abbreviation:  Scand. J. Rheumatol.     Publication Date:  1994  
Date Detail:
Created Date:  1994-12-02     Completed Date:  1994-12-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0321213     Medline TA:  Scand J Rheumatol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  223-30     Citation Subset:  IM    
Rheumatism Research Unit, Aarhus University, Denmark.
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MeSH Terms
Arthritis, Rheumatoid / diagnosis,  drug therapy*,  immunology
Blood Sedimentation
Cohort Studies
Finger Joint / physiology,  radiography
Gold Sodium Thiomalate / therapeutic use*
Longitudinal Studies
Middle Aged
Toe Joint / physiology,  radiography
Treatment Outcome
Reg. No./Substance:
12244-57-4/Gold Sodium Thiomalate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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