Document Detail

The course of neurocognition and social functioning in individuals at ultra high risk for psychosis.
MedLine Citation:
PMID:  17420177     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study evaluates longitudinal neuropsychological performance and its association with clinical symptomatology and psychosocial outcome in individuals identified as ultra high risk (UHR) for psychosis. METHODS: Thirty-five UHR individuals completed neurocognitive, clinical, and social/role functioning assessments at baseline and, on average, 8.3 months later. RESULTS: UHR subjects showed significant cognitive deficits at baseline and 2 distinct profiles of cognitive change over time. On average, 50% demonstrated improvement in social and role functioning over the follow-up period, while the other half showed either stability or decline in functioning. Functional improvement was associated with improved processing speed and visual memory, as well as improvement in clinical symptoms over the follow-up period. In contrast, patients who did not improve functionally showed stable clinical symptoms and cognitive performance over time. CONCLUSIONS: Although the degree of neurocognitive deficit at baseline in UHR patients does not predict psychosocial outcome, the course of neurocognitive change over the first 8 months of follow-up does differentiate patients with good and poor functional outcomes.
Tara A Niendam; Carrie E Bearden; Jamie Zinberg; Jennifer K Johnson; Mary O'Brien; Tyrone D Cannon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-04-09
Journal Detail:
Title:  Schizophrenia bulletin     Volume:  33     ISSN:  0586-7614     ISO Abbreviation:  Schizophr Bull     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-18     Completed Date:  2007-08-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0236760     Medline TA:  Schizophr Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  772-81     Citation Subset:  IM    
Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095-1563, USA.
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MeSH Terms
Cognition Disorders / diagnosis*,  genetics,  psychology
Disease Progression
Early Diagnosis
Longitudinal Studies
Neuropsychological Tests*
Psychiatric Status Rating Scales
Psychotic Disorders / diagnosis*,  genetics,  psychology
Risk Factors
Schizophrenia / diagnosis*,  genetics
Schizophrenic Psychology*
Schizotypal Personality Disorder / diagnosis*,  genetics,  psychology
Social Adjustment*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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