Document Detail

The course of experimental myocardial infarction under conditions of Suppressed and enhanced NO synthesis.
MedLine Citation:
PMID:  16027859     Owner:  NLM     Status:  MEDLINE    
Experimental myocardial infarction (coronary ligation without drug infusion) reduced heart rate, stroke volume, cardiac output, and blood pressure. Under conditions of blocked NO synthesis, experimental myocardial infarction was accompanied by a transient increase in heart rate, stroke volume, cardiac output, and blood pressure, followed by their decrease throughout the experiment. Experimental myocardial infarction against the background of L-arginine treatment increased all these parameters with their subsequent stabilization at the attained level. Animal survival after administration of L-arginine was 80% vs. 33 in the control, and 22% after administration of L-NAME. It can be hypothesized that L-arginine possesses an intrinsic NO-independent cardioprotective effect.
F F Rakhmatullina; A G Nasyrov; A L Zefirov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  139     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-07-19     Completed Date:  2006-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  384-7     Citation Subset:  IM    
Department of Normal Physiology, Kazan State Medical University, Russia.
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MeSH Terms
Arginine / metabolism
Enzyme Inhibitors / pharmacology
Myocardial Infarction / metabolism,  pathology*
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / biosynthesis*
Nitric Oxide Synthase / antagonists & inhibitors
Reg. No./Substance:
0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; EC Oxide Synthase

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