Document Detail


The course of experimental myocardial infarction under conditions of Suppressed and enhanced NO synthesis.
MedLine Citation:
PMID:  16027859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experimental myocardial infarction (coronary ligation without drug infusion) reduced heart rate, stroke volume, cardiac output, and blood pressure. Under conditions of blocked NO synthesis, experimental myocardial infarction was accompanied by a transient increase in heart rate, stroke volume, cardiac output, and blood pressure, followed by their decrease throughout the experiment. Experimental myocardial infarction against the background of L-arginine treatment increased all these parameters with their subsequent stabilization at the attained level. Animal survival after administration of L-arginine was 80% vs. 33 in the control, and 22% after administration of L-NAME. It can be hypothesized that L-arginine possesses an intrinsic NO-independent cardioprotective effect.
Authors:
F F Rakhmatullina; A G Nasyrov; A L Zefirov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  139     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-07-19     Completed Date:  2006-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  384-7     Citation Subset:  IM    
Affiliation:
Department of Normal Physiology, Kazan State Medical University, Russia. rachmat@mail.ru
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MeSH Terms
Descriptor/Qualifier:
Animals
Arginine / metabolism
Enzyme Inhibitors / pharmacology
Male
Myocardial Infarction / metabolism,  pathology*
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / biosynthesis*
Nitric Oxide Synthase / antagonists & inhibitors
Rats
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; EC 1.14.13.39/Nitric Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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